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Panama City Vacations

Pack those stellar shades. We have Panama City vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Panama City – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Panama City vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Panama City

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Panama City vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Panama City well.

Top Hotel Deals

See all 153 Hotels in Panama City
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
4.5 out of 5.0

This family-friendly Panama City hotel is located by the ocean, within 1 mi (2 km) of Multicentro Panama and Via Espana. Multiplaza Pacific Mall is 1.8 mi (2.9 ...

$151

$151
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0

This family-friendly Panama City hotel is located on the waterfront, within 1 mi (2 km) of Multicentro Panama and Multiplaza Pacific Mall. Via Espana and National ...

$159

$159
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0

Located in El Cangrejo, this hotel is within a 15-minute walk of Theater Circle, National Shrine of the Heart of Mary, and Via Espana. Colonial Religious Art ...

RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.5 out of 5.0

Located in the heart of Bella Vista, this spa hotel is 0.3 mi (0.5 km) from National Shrine of the Heart of Mary and 2.8 mi (4.4 km) from Metropolitan Cathedral ...

$89

$89
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0

Situated in Bella Vista, this hotel is 0.2 mi (0.3 km) from Via Espana and 2.5 mi (4.1 km) from Metropolitan Cathedral of Panama. National Shrine of the Heart ...

TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0

Located in El Cangrejo, this hotel is 0.5 mi (0.8 km) from Via Espana and 2.8 mi (4.6 km) from Metropolitan Cathedral of Panama. National Shrine of the Heart ...

$59

$59
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0

Located in the heart of Bella Vista, this luxury hotel is 0.7 mi (1.1 km) from Via Espana and 2.4 mi (3.8 km) from Metropolitan Cathedral of Panama. Multicentro ...

$129

$129
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla, Panama City
4.0 out of 5.0

Located in Punta Paitilla, this hotel is within 1 mi (2 km) of Multicentro Panama and National Shrine of the Heart of Mary. Multiplaza Pacific Mall and Via Espana ...

$73

$73
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0

Located in the heart of Panama City, this hotel is within 1 mi (2 km) of Albrook Shopping Mall and Anthropological Museum Reina Torres de Arauz. Metropolitan ...

Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0

Located in the heart of Bella Vista, this luxury hotel is 0.3 mi (0.4 km) from Via Espana and 2.6 mi (4.2 km) from Metropolitan Cathedral of Panama. National ...

$144

$144

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.