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Southeast Illinois

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Southeast Illinois Flights as Low as $531

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Fri, Jul 4 - Sat, Jul 5
SAT
San Antonio Intl.
MWA
Williamson County Regional
$531 Roundtrip, found 6 days ago
$531
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Sat, Jul 5, priced at $531 found 6 days ago
American Airlines
Tue, Jul 1 - Wed, Jul 2
SAT
San Antonio Intl.
MWA
Williamson County Regional
$534 Roundtrip, found 5 days ago
$534
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jul 1 from San Antonio Intl. to Williamson County Regional, returning Wed, Jul 2, priced at $534 found 5 days ago
United
Fri, Jul 4 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$541 Roundtrip, found 3 days ago
$541
Roundtrip
found 3 days ago
Select United flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $541 found 3 days ago
American Airlines
Fri, Jul 4 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$542 Roundtrip, found 5 days ago
$542
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $542 found 5 days ago
American Airlines
Tue, Jul 1 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$544 Roundtrip, found 3 days ago
$544
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jul 1 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $544 found 3 days ago
American Airlines
Tue, Jul 1 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$545 Roundtrip, found 5 days ago
$545
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jul 1 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $545 found 5 days ago
United
Fri, Jul 4 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$546 Roundtrip, found 6 days ago
$546
Roundtrip
found 6 days ago
Select United flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $546 found 6 days ago
American Airlines
Fri, Jul 4 - Sat, Jul 5
SAT
San Antonio Intl.
MWA
Williamson County Regional
$555 Roundtrip, found 4 days ago
$555
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Sat, Jul 5, priced at $555 found 4 days ago
United
Mon, Jun 30 - Tue, Jul 1
SAT
San Antonio Intl.
MWA
Williamson County Regional
$558 Roundtrip, found 4 days ago
$558
Roundtrip
found 4 days ago
Select United flight, departing Mon, Jun 30 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 1, priced at $558 found 4 days ago
United
Fri, Jul 4 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$566 Roundtrip, found 4 days ago
$566
Roundtrip
found 4 days ago
Select United flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $566 found 4 days ago
American Airlines
Sat, Jul 5 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$567 Roundtrip, found 5 days ago
$567
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Jul 5 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $567 found 5 days ago
United
Mon, Jun 30 - Wed, Jul 2
SAT
San Antonio Intl.
MWA
Williamson County Regional
$568 Roundtrip, found 4 days ago
$568
Roundtrip
found 4 days ago
Select United flight, departing Mon, Jun 30 from San Antonio Intl. to Williamson County Regional, returning Wed, Jul 2, priced at $568 found 4 days ago
American Airlines
Mon, Jun 30 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$569 Roundtrip, found 6 days ago
$569
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Jun 30 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $569 found 6 days ago
American Airlines
Mon, Jun 30 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$570 Roundtrip, found 6 days ago
$570
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Jun 30 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $570 found 6 days ago
American Airlines
Fri, Jul 4 - Sat, Jul 5
SAT
San Antonio Intl.
MWA
Williamson County Regional
$572 Roundtrip, found 5 days ago
$572
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Sat, Jul 5, priced at $572 found 5 days ago
American Airlines
Fri, Jul 4 - Tue, Jul 8
SAT
San Antonio Intl.
MWA
Williamson County Regional
$582 Roundtrip, found 3 days ago
$582
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Williamson County Regional, returning Tue, Jul 8, priced at $582 found 3 days ago

Cheap Flights to Southeast Illinois

Fall in love at first flight with your vacation to Southeast Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MDH airport.

What is the cheapest month to fly to Southeast Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Illinois are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Illinois.

What airport is best to fly into Southeast Illinois?

When you’re planning your trip to Southeast Illinois, convenience is the name of the game. Luckily, Southeast Illinois Evansville Regional Airport is nearby so you can deplane and get going on checking off everything on your Southeast Illinois must-do list.

How much are flights to Southeast Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $531, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Illinois?

The trick to saving a stack of cash on your flight to Southeast Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $531 right now, why wait?

Southeast Illinois Flight Information
Destination airport
Decatur
Destination airport IATA code
DEC
Roundtrip price
$393

Last Minute Hotel Deals in Southeast Illinois

Baymont by Wyndham Effingham
Baymont by Wyndham Effingham
2.5 out of 5
1811 W Fayette Avenue, I-57 & 70 Exit 159, Effingham, IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (910 reviews)
"Very easy access Excellent food Very friendly staff Room was nice & clean"

Reviewed on Jun 15, 2025

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Baymont by Wyndham Effingham
La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham Effingham
3 out of 5
1103 Avenue Of Mid America, Effingham, IL
Stay at this 3-star business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,003 reviews)
"The night auditor, Sammy was super cool. He made coffee and offered some to me right after I got done bringing in my family’s bags. It was super late and I was worn out but his kindness made my exhaustion minimal. Thank you Sammy."

Reviewed on Jun 20, 2025

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La Quinta Inn & Suites by Wyndham Effingham
Suite Dreams Hotel
Suite Dreams Hotel
2.5 out of 5
300 Broadway Avenue East, Mattoon, IL
Book a stay at this business-friendly hotel in Mattoon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (472 reviews)
"Great"

Reviewed on Jun 3, 2025

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Suite Dreams Hotel
Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, IL
2.5 out of 5
1200 N Raney, Effingham, IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,010 reviews)
"Excellent service."

Reviewed on Jun 19, 2025

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Country Inn & Suites by Radisson, Effingham, IL
Ramada by Wyndham Effingham
Ramada by Wyndham Effingham
3 out of 5
1606 W Fayette Avenue, Effingham, IL
Stay at this 3-star business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (951 reviews)
"It was clean, up-to-date, and convenient. The price was right. I will stay here in the future when passing through this way."

Reviewed on Jun 15, 2025

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Ramada by Wyndham Effingham
Days Inn & Suites by Wyndham Casey
Days Inn & Suites by Wyndham Casey
2 out of 5
933 N Route 49, Casey, IL
Book a stay at this business-friendly hotel in Casey. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.4/10 Good! (718 reviews)
"It was a nice comfortable room. We enjoyed the unique town as well."

Reviewed on Jun 13, 2025

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Days Inn & Suites by Wyndham Casey
Comfort Suites Mattoon
Comfort Suites Mattoon
2.5 out of 5
1408 Broadway Ave E, Mattoon, IL
Book a stay at this business-friendly hotel in Mattoon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (757 reviews)
"It was close to a good selection of restaurants and stores. Staff was friendly and welcoming. Area surrounding the hotel is a little "tired" looking and felt sketchy, but the hotel itself was nice and quiet."

Reviewed on Jun 19, 2025

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Comfort Suites Mattoon
Economy Inn & Suites
Economy Inn & Suites
2 out of 5
411 E Poplar St, Harrisburg, IL
Stay at this hotel in Harrisburg. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Harrisburg Township Park District and Shawnee ...
8.4/10 Very Good! (29 reviews)
"Staff was great, clean room and comfortable"

Reviewed on Jun 19, 2025

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Economy Inn & Suites
See all 938 properties in Southeast Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.