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Southeast Illinois

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Southeast Illinois Flights as Low as $383

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Fri, Aug 22 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$383 Roundtrip, found 4 days ago
$383
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $383 found 4 days ago
American Airlines
Fri, Aug 22 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$413 Roundtrip, found 4 days ago
$413
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $413 found 4 days ago
American Airlines
Fri, Aug 22 - Sun, Aug 24
DEN
Denver Intl.
PAH
Barkley Regional
$418 Roundtrip, found 4 days ago
$418
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Sun, Aug 24, priced at $418 found 4 days ago
American Airlines
Fri, Aug 22 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$431 Roundtrip, found 5 days ago
$431
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $431 found 5 days ago
American Airlines
Tue, Aug 19 - Fri, Aug 22
DEN
Denver Intl.
PAH
Barkley Regional
$450 Roundtrip, found 6 days ago
$450
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Aug 19 from Denver Intl. to Barkley Regional, returning Fri, Aug 22, priced at $450 found 6 days ago
American Airlines
Sat, Aug 23 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$452 Roundtrip, found 5 days ago
$452
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Aug 23 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $452 found 5 days ago
American Airlines
Wed, Aug 20 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$452 Roundtrip, found 6 days ago
$452
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Aug 20 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $452 found 6 days ago
American Airlines
Thu, Aug 21 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$453 Roundtrip, found 4 days ago
$453
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Aug 21 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $453 found 4 days ago
American Airlines
Tue, Aug 19 - Fri, Aug 22
DEN
Denver Intl.
PAH
Barkley Regional
$460 Roundtrip, found 4 days ago
$460
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Aug 19 from Denver Intl. to Barkley Regional, returning Fri, Aug 22, priced at $460 found 4 days ago
American Airlines
Thu, Aug 21 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$461 Roundtrip, found 1 day ago
$461
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 21 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $461 found 1 day ago
American Airlines
Fri, Aug 22 - Wed, Aug 27
DEN
Denver Intl.
PAH
Barkley Regional
$462 Roundtrip, found 5 days ago
$462
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Wed, Aug 27, priced at $462 found 5 days ago
American Airlines
Wed, Aug 20 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$463 Roundtrip, found 5 days ago
$463
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 20 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $463 found 5 days ago
American Airlines
Fri, Aug 22 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$464 Roundtrip, found 1 day ago
$464
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $464 found 1 day ago
American Airlines
Tue, Aug 19 - Wed, Aug 20
DEN
Denver Intl.
PAH
Barkley Regional
$466 Roundtrip, found 4 days ago
$466
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Aug 19 from Denver Intl. to Barkley Regional, returning Wed, Aug 20, priced at $466 found 4 days ago
American Airlines
Thu, Aug 21 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$471 Roundtrip, found 1 day ago
$471
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 21 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $471 found 1 day ago
American Airlines
Thu, Aug 21 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$471 Roundtrip, found 1 day ago
$471
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 21 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $471 found 1 day ago

Cheap Flights to Southeast Illinois

Fall in love at first flight with your vacation to Southeast Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MDH airport.

What is the cheapest month to fly to Southeast Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Illinois are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Illinois.

What airport is best to fly into Southeast Illinois?

When you’re planning your trip to Southeast Illinois, convenience is the name of the game. Luckily, Southeast Illinois Evansville Regional Airport is nearby so you can deplane and get going on checking off everything on your Southeast Illinois must-do list.

How much are flights to Southeast Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $383, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Illinois?

The trick to saving a stack of cash on your flight to Southeast Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $383 right now, why wait?

Southeast Illinois Flight Information
Destination airport
Barkley Regional
Destination airport IATA code
PAH
Roundtrip price
$382

Last Minute Hotel Deals in Southeast Illinois

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 out of 5
1200 N Raney, Effingham, IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,003 reviews)
"Na"

Reviewed on Aug 2, 2025

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Country Inn & Suites by Radisson, Effingham, IL
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

3 out of 5
1103 Avenue Of Mid America, Effingham, IL
Stay at this 3-star business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,010 reviews)
"It is a nice clean place to stay"

Reviewed on Aug 5, 2025

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La Quinta Inn & Suites by Wyndham Effingham
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

2.5 out of 5
1811 W Fayette Avenue, I-57 & 70 Exit 159, Effingham, IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (938 reviews)
"Adequate for a quick stop. Has limited eating establishments in the area."

Reviewed on Aug 2, 2025

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Baymont by Wyndham Effingham
Economy Inn & Suites

Economy Inn & Suites

2 out of 5
411 E Poplar St, Harrisburg, IL
Book a stay at this business-friendly hotel in Harrisburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Harrisburg Township Park District ...
8/10 Very Good! (52 reviews)
"The couple who owns it were very welcoming and check in was smooth. We could tell that they have made a lot of upgrades/renovation and everything was clean. The only complaint was the air-conditioning struggled to keep the room very cool even at max all night. To be fair the heat index was over 100° ..."

Reviewed on Aug 5, 2025

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Economy Inn & Suites
Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

2.5 out of 5
2179 East 5th Street, Metropolis, IL
Book a stay at this business-friendly hotel in Metropolis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (999 reviews)
"Property was clean."

Reviewed on Aug 3, 2025

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Holiday Inn Express Metropolis by IHG
Days Inn & Suites by Wyndham Casey

Days Inn & Suites by Wyndham Casey

2 out of 5
933 N Route 49, Casey, IL
Book a stay at this business-friendly hotel in Casey. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.4/10 Good! (755 reviews)
"Great location and a quite place to stay and relax"

Reviewed on Jul 13, 2025

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Days Inn & Suites by Wyndham Casey
Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG

3.5 out of 5
1301 Avenue Of Mid America, Effingham, IL
Stay at this 3.5-star business-friendly hotel in Effingham. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
9/10 Wonderful! (626 reviews)
"Great"

Reviewed on Jul 24, 2025

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Holiday Inn Effingham by IHG
Unique Suites Hotel

Unique Suites Hotel

2.5 out of 5
920 W Lincoln Ave, Charleston, IL
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (663 reviews)
Just what we needed
"Overall me & my family enjoyed our stay. The AC wasn’t as strong as we would have liked & the bed was smaller than I imagined. It was soo hot in the lobby & we had to wait to check in. But the pool was really nice & the property was well kept. I would stay again."

Reviewed on Jul 27, 2025

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Unique Suites Hotel
See all 954 properties in Southeast Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.