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Santa Isabel

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Santa Isabel Flights as Low as $216

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Mon, Aug 31 - Fri, Sep 11
PHL
Philadelphia Intl.
SJU
Luis Munoz Marin Intl.
$216 Roundtrip, found 5 hours ago
$216
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Mon, Aug 31 from Philadelphia Intl. to Luis Munoz Marin Intl., returning Fri, Sep 11, priced at $216 found 5 hours ago
Frontier Airlines
Wed, Aug 5 - Thu, Aug 13
MCO
Orlando Intl.
SJU
Luis Munoz Marin Intl.
$220 Roundtrip, found 1 day ago
$220
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Aug 5 from Orlando Intl. to Luis Munoz Marin Intl., returning Thu, Aug 13, priced at $220 found 1 day ago
Frontier Airlines
Tue, Aug 4 - Wed, Aug 19
LGA
LaGuardia
SJU
Luis Munoz Marin Intl.
$236 Roundtrip, found 12 hours ago
$236
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Tue, Aug 4 from LaGuardia to Luis Munoz Marin Intl., returning Wed, Aug 19, priced at $236 found 12 hours ago
Frontier Airlines
Sat, May 30 - Fri, Jun 5
MCO
Orlando Intl.
BQN
Rafael Hernandez
$241 Roundtrip, found 3 days ago
$241
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sat, May 30 from Orlando Intl. to Rafael Hernandez, returning Fri, Jun 5, priced at $241 found 3 days ago
Frontier Airlines
Tue, Jul 28 - Fri, Aug 7
MCO
Orlando Intl.
PSE
Mercedita
$247 Roundtrip, found 12 hours ago
$247
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Tue, Jul 28 from Orlando Intl. to Mercedita, returning Fri, Aug 7, priced at $247 found 12 hours ago
Frontier Airlines
Tue, Aug 25 - Mon, Aug 31
TTN
Mercer
SJU
Luis Munoz Marin Intl.
$256 Roundtrip, found 5 hours ago
$256
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Tue, Aug 25 from Mercer to Luis Munoz Marin Intl., returning Mon, Aug 31, priced at $256 found 5 hours ago
Frontier Airlines
Sat, Jul 4 - Sat, Jul 11
TTN
Mercer
BQN
Rafael Hernandez
$258 Roundtrip, found 5 days ago
$258
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sat, Jul 4 from Mercer to Rafael Hernandez, returning Sat, Jul 11, priced at $258 found 5 days ago
Frontier Airlines
Thu, Aug 13 - Fri, Aug 21
PHL
Philadelphia Intl.
BQN
Rafael Hernandez
$276 Roundtrip, just found
$276
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Aug 13 from Philadelphia Intl. to Rafael Hernandez, returning Fri, Aug 21, priced at $276 just found
Frontier Airlines
Sat, Jul 18 - Wed, Aug 5
LGA
LaGuardia
BQN
Rafael Hernandez
$276 Roundtrip, found 10 hours ago
$276
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Sat, Jul 18 from LaGuardia to Rafael Hernandez, returning Wed, Aug 5, priced at $276 found 10 hours ago
JetBlue Airways
Tue, May 26 - Tue, Jun 2
MCO
Orlando Intl.
BQN
Rafael Hernandez
$283 Roundtrip, found 3 days ago
$283
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Tue, May 26 from Orlando Intl. to Rafael Hernandez, returning Tue, Jun 2, priced at $283 found 3 days ago
American Airlines
Mon, Aug 24 - Tue, Aug 25
TTN
Mercer
SJU
Luis Munoz Marin Intl.
$288 Roundtrip, found 7 hours ago
$288
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Aug 24 from Mercer to Luis Munoz Marin Intl., returning Tue, Aug 25, priced at $288 found 7 hours ago
Frontier Airlines
Mon, Jun 1 - Fri, Jun 12
LGA
LaGuardia
PSE
Mercedita
$321 Roundtrip, found 18 hours ago
$321
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Mon, Jun 1 from LaGuardia to Mercedita, returning Fri, Jun 12, priced at $321 found 18 hours ago
Frontier Airlines
Thu, May 14 - Thu, May 21
TTN
Mercer
PSE
Mercedita
$376 Roundtrip, just found
$376
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, May 14 from Mercer to Mercedita, returning Thu, May 21, priced at $376 just found
Frontier Airlines
Thu, May 14 - Thu, May 21
PHL
Philadelphia Intl.
PSE
Mercedita
$376 Roundtrip, just found
$376
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, May 14 from Philadelphia Intl. to Mercedita, returning Thu, May 21, priced at $376 just found
JetBlue Airways
Tue, Jul 21 - Tue, Aug 4
LGA
LaGuardia
MAZ
Eugenio María de Hostos
$579 Roundtrip, just found
$579
Roundtrip
just found
Select JetBlue Airways flight, departing Tue, Jul 21 from LaGuardia to Eugenio María de Hostos, returning Tue, Aug 4, priced at $579 just found
JetBlue Airways
Wed, May 27 - Fri, Jun 5
PHL
Philadelphia Intl.
MAZ
Eugenio María de Hostos
$690 Roundtrip, found 3 days ago
$690
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Wed, May 27 from Philadelphia Intl. to Eugenio María de Hostos, returning Fri, Jun 5, priced at $690 found 3 days ago

Cheap Flights to Santa Isabel

Fall in love at first flight with your vacation to Santa Isabel by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Isabel on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Isabel, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Isabel

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Isabel with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the SJU airport.

What is the cheapest month to fly to Santa Isabel?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Isabel are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Isabel?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Isabel.

What airport is best to fly into Santa Isabel?

When you’re planning your trip to Santa Isabel, convenience is the name of the game. Luckily, Santa Isabel Mercedita Airport is nearby so you can deplane and get going on checking off everything on your Santa Isabel must-do list.

How much are flights to Santa Isabel?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Isabel on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $216, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Isabel?

The trick to saving a stack of cash on your flight to Santa Isabel? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $216 right now, why wait?

Santa Isabel Flight Information
Destination airport
Luis Munoz Marin Intl.
Destination airport IATA code
SJU
Roundtrip price
$187

Last Minute Hotel Deals in Santa Isabel

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9 Santa Isabel
Stay at this motel in Santa Isabel. Enjoy 24-hour room service, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (346 reviews)
Not sure if there was a vending machine, ice maker or microwave. It would be great to have some kind of food when it is late at night. Not sure if they have a kitchen where they could be a microwave and ice maker. I did not ask for these, but also there were no sign of them having them. There is ...

Reviewed on May 5, 2026

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Hotel Las Vegas
Hacienda del Sur

Hacienda del Sur

2 out of 5
Carr 545 KM 1.5, Sector Gabia Santa Isabel
Stay at this hotel in Santa Isabel. Enjoy free WiFi, free parking, and a garden. Popular attractions Carribbean Cinemas Santa Isabel and Coamo Springs are located ...
9.8/10 Exceptional! (42 reviews)
Lugar acogedor y el personal muy atento.

Reviewed on Apr 20, 2026

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Hacienda del Sur
Hilton Ponce Golf & Casino Resort

Hilton Ponce Golf & Casino Resort

4.5 out of 5
1150 Caribe Avenue Ponce
Book a stay at this luxury resort in Ponce. Enjoy free WiFi, 2 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our ...
8.8/10 Excellent! (1,016 reviews)
Everything was great but for the size of the hotel the pool is too small. It needs another pool

Reviewed on May 11, 2026

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Hilton Ponce Golf & Casino Resort
Spark by Hilton Ponce

Spark by Hilton Ponce

3.5 out of 5
103 Turpo Industrial Park Ponce
Book a stay at this business-friendly hotel in Ponce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
8.6/10 Excellent! (1,683 reviews)
The property was very well maintain and the staff very friendly and attentive. Good service.

Reviewed on May 11, 2026

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Spark by Hilton Ponce
Ponce Plaza Hotel & Casino

Ponce Plaza Hotel & Casino

3.5 out of 5
Reina Street Ponce
Book a stay at this historic hotel in Ponce. Enjoy free WiFi, a casino, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
9.2/10 Wonderful! (1,051 reviews)
Beautiful hotel, very attentive staff.

Reviewed on May 11, 2026

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Ponce Plaza Hotel & Casino
Aloft Ponce Hotel & Casino

Aloft Ponce Hotel & Casino

3.5 out of 5
Street No 2 KM 228.9 Ponce
Stay at this hotel in Ponce. Enjoy free parking, 2 outdoor pools, and 4 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (1,206 reviews)
No hot water for 2 days

Reviewed on May 9, 2026

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Aloft Ponce Hotel & Casino
Hotel Vista Bahia & Marina

Hotel Vista Bahia & Marina

3 out of 5
296 Cll A Salinas Salinas
Stay at this property in Salinas. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Marina de Salinas and Playa La Ochenta are located ...
8.8/10 Excellent! (139 reviews)
Hotel was good, staff was very nice and helpful. But online it says all inclusive and it’s not, you have to pay an additional fee for it to be all inclusive.

Reviewed on May 11, 2026

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Hotel Vista Bahia & Marina
Holiday Inn Ponce & Tropical Casino by IHG

Holiday Inn Ponce & Tropical Casino by IHG

3.5 out of 5
3315 Ponce By Pass Ponce
Stay at this hotel in Ponce. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff in our reviews. Popular attractions Carribbean ...
9/10 Wonderful! (1,013 reviews)
Beautiful!

Reviewed on May 9, 2026

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Holiday Inn Ponce & Tropical Casino by IHG
See all 321 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.