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Grimes

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Grimes Flights as Low as $162

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Jul 29 - Wed, Aug 5
DEN
Denver Intl.
DSM
Des Moines Intl.
$162 Roundtrip, found 18 hours ago
$162
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Wed, Jul 29 from Denver Intl. to Des Moines Intl., returning Wed, Aug 5, priced at $162 found 18 hours ago
Bargain Flight
Mon, Jun 29 - Fri, Jul 17
DCA
Ronald Reagan Washington National
DSM
Des Moines Intl.
$250 Roundtrip, found 12 hours ago
$250
Roundtrip
found 12 hours ago
Select Bargain Flight flight, departing Mon, Jun 29 from Ronald Reagan Washington National to Des Moines Intl., returning Fri, Jul 17, priced at $250 found 12 hours ago
Frontier Airlines
Fri, Sep 11 - Mon, Sep 14
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$264 Roundtrip, found 16 hours ago
$264
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Fri, Sep 11 from George Bush Intercontinental to Des Moines Intl., returning Mon, Sep 14, priced at $264 found 16 hours ago
Bargain Flight
Tue, Jul 28 - Tue, Aug 4
LAX
Los Angeles Intl.
DSM
Des Moines Intl.
$280 Roundtrip, found 12 hours ago
$280
Roundtrip
found 12 hours ago
Select Bargain Flight flight, departing Tue, Jul 28 from Los Angeles Intl. to Des Moines Intl., returning Tue, Aug 4, priced at $280 found 12 hours ago
Delta
Thu, Jul 30 - Tue, Aug 4
DEN
Denver Intl.
DSM
Des Moines Intl.
$281 Roundtrip, found 2 days ago
$281
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Jul 30 from Denver Intl. to Des Moines Intl., returning Tue, Aug 4, priced at $281 found 2 days ago
Delta
Wed, Sep 9 - Tue, Sep 15
HOU
William P. Hobby
DSM
Des Moines Intl.
$289 Roundtrip, found 16 hours ago
$289
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, Sep 9 from William P. Hobby to Des Moines Intl., returning Tue, Sep 15, priced at $289 found 16 hours ago
American Airlines
Fri, Sep 11 - Mon, Sep 14
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$289 Roundtrip, found 16 hours ago
$289
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Fri, Sep 11 from George Bush Intercontinental to Des Moines Intl., returning Mon, Sep 14, priced at $289 found 16 hours ago
American Airlines
Tue, Jul 28 - Tue, Aug 11
CAE
Columbia Metropolitan
DSM
Des Moines Intl.
$291 Roundtrip, found 1 day ago
$291
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 28 from Columbia Metropolitan to Des Moines Intl., returning Tue, Aug 11, priced at $291 found 1 day ago
Bargain Flight
Tue, Jul 28 - Wed, Aug 5
PBI
Palm Beach Intl.
DSM
Des Moines Intl.
$297 Roundtrip, found 1 day ago
$297
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jul 28 from Palm Beach Intl. to Des Moines Intl., returning Wed, Aug 5, priced at $297 found 1 day ago
Delta
Sat, Sep 12 - Tue, Sep 15
LFT
Lafayette Regional
DSM
Des Moines Intl.
$309 Roundtrip, found 16 hours ago
$309
Roundtrip
found 16 hours ago
Select Delta flight, departing Sat, Sep 12 from Lafayette Regional to Des Moines Intl., returning Tue, Sep 15, priced at $309 found 16 hours ago
Delta
Tue, Jul 7 - Tue, Jul 14
EWR
Newark Liberty Intl. Airport
DSM
Des Moines Intl.
$329 Roundtrip, found 6 days ago
$329
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jul 7 from Newark Liberty Intl. Airport to Des Moines Intl., returning Tue, Jul 14, priced at $329 found 6 days ago
Delta
Tue, Aug 25 - Wed, Aug 26
GEG
Spokane Intl.
DSM
Des Moines Intl.
$333 Roundtrip, found 1 day ago
$333
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Aug 25 from Spokane Intl. to Des Moines Intl., returning Wed, Aug 26, priced at $333 found 1 day ago
American Airlines
Tue, Jul 28 - Tue, Aug 4
RSW
Southwest Florida Intl.
DSM
Des Moines Intl.
$341 Roundtrip, found 12 hours ago
$341
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Tue, Jul 28 from Southwest Florida Intl. to Des Moines Intl., returning Tue, Aug 4, priced at $341 found 12 hours ago
United
Tue, Jun 16 - Tue, Jun 30
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$467 Roundtrip, found 16 hours ago
$467
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 16 from O'Hare Intl. to Des Moines Intl., returning Tue, Jun 30, priced at $467 found 16 hours ago
United
Thu, Jun 25 - Wed, Jul 8
SFO
San Francisco Intl.
DSM
Des Moines Intl.
$686 Roundtrip, found 11 hours ago
$686
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Jun 25 from San Francisco Intl. to Des Moines Intl., returning Wed, Jul 8, priced at $686 found 11 hours ago
Alaska Airlines
Thu, Jun 25 - Wed, Jul 8
SFO
San Francisco Intl.
DSM
Des Moines Intl.
$1,061 Roundtrip, found 11 hours ago
$1,061
Roundtrip
found 11 hours ago
Select Alaska Airlines flight, departing Thu, Jun 25 from San Francisco Intl. to Des Moines Intl., returning Wed, Jul 8, priced at $1,061 found 11 hours ago

Cheap Flights to Grimes

Fall in love at first flight with your vacation to Grimes by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Grimes on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Grimes, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Grimes

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Grimes with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to Grimes?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Grimes are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Grimes?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Grimes.

What airport is best to fly into Grimes?

When you’re planning your trip to Grimes, convenience is the name of the game. Luckily, Grimes Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your Grimes must-do list.

How much are flights to Grimes?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Grimes on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $162, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Grimes?

The trick to saving a stack of cash on your flight to Grimes? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $162 right now, why wait?

Grimes Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$162

Last Minute Hotel Deals in Grimes

Red Lion Inn & Suites Grimes

Red Lion Inn & Suites Grimes

2.5 out of 5
251 Gateway Cir Grimes IA
Book a stay at this business-friendly hotel in Grimes. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (631 reviews)
"The room was amazing and clean. The staff was friendly and helpful. Would Absolutely stay here again"

Reviewed on Jun 7, 2026

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Red Lion Inn & Suites Grimes
Tru By Hilton Grimes Des Moines

Tru By Hilton Grimes Des Moines

2.5 out of 5
701 NE Gateway Drive Grimes IA
Stay at this hotel in Grimes. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pole Position Raceway and Sky Zone Indoor Trampoline Park ...
9.2/10 Wonderful! (58 reviews)
"Todo excelente"

Reviewed on Jun 13, 2026

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Tru By Hilton Grimes Des Moines
Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton

4.5 out of 5
1000 Walnut St Des Moines IA
Book a stay at this luxury hotel in Des Moines. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms ...
9.6/10 Exceptional! (1,186 reviews)
"It was great"

Reviewed on Jun 11, 2026

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Hotel Fort Des Moines, Curio Collection by Hilton
Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West

3 out of 5
7225 Vista Dr West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,018 reviews)
"roof leaked onto bed and they knew that room was a problem"

Reviewed on Jun 13, 2026

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Fairfield Inn and Suites by Marriott Des Moines West
Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,822 reviews)
"Parking was easy and spacious, stayed in a non-smoking room and didn’t have a whiff of smoke at all. Can’t comment on breakfast as we chose to sleep in, but from 4am-10am the longest I’ve ever seen from a hotel which was awesome. Rooms were clean and spacious, the bed was comfortable and the bathroom ..."

Reviewed on Jun 12, 2026

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Days Inn & Suites by Wyndham Des Moines Airport
Drury Inn & Suites West Des Moines

Drury Inn & Suites West Des Moines

3 out of 5
5505 Mills Civic Pkwy West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,062 reviews)
"Good hot breakfast. Friendly staff. Very clean room."

Reviewed on Jun 13, 2026

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Drury Inn & Suites West Des Moines
Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University

3 out of 5
2650 University Ave. Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (1,032 reviews)
"Great central location for my leadership classes at Drake plus central to get to several local spots for a brewery or good food."

Reviewed on Jun 13, 2026

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Home2 Suites by Hilton Des Moines at Drake University
Des Lux Hotel

Des Lux Hotel

3.5 out of 5
800 Locust St Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.8/10 Exceptional! (1,083 reviews)
"Staff was great, we really appreciated the gift card for 801 Chophouse when we mentioned we were going there for our anniversary dinner. The only issue with the room was that there was shampoo or soap on the shower floor, when I stepped in. I slipped and almost fell. The room is very noisy Also, ..."

Reviewed on Jun 14, 2026

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Des Lux Hotel
See all 838 properties in Grimes
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.