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Last Minute Hot Rate® Hotel Deals in St. Charles

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Choose from 495 St. Charles Hotel Deals

Quality Inn near Medical Center
Quality Inn near Medical Center
2.5 out of 5
5708 Bandel Road NW, Rochester, MN
  • 12 min drive from Mayo Clinic
The price is $63 per night from May 12 to May 13
$63
per night
May 12 - May 13
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (471 reviews)
"Easy access to the mayo clinic..the rooms and food was very good..would stay there again"

Reviewed on May 3, 2024

Quality Inn near Medical Center
Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
The price is $149 per night from May 9 to May 10
$149
per night
May 9 - May 10
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (1,005 reviews)
"We love staying at the Kahler"

Reviewed on Apr 29, 2024

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $80 per night from May 28 to May 29
$80
per night
May 28 - May 29
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (272 reviews)
"Was nice to have a ground floor room with our small dog with us. The room was not able to be kept warm (even with heater unit set at 84) I think due to a leaky air door."

Reviewed on May 3, 2024

AmericInn by Wyndham Rochester Near Mayo Clinic
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
The price is $107 per night from May 10 to May 11
$107
per night
May 10 - May 11
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the breakfast and ...
9.4/10 Exceptional! (566 reviews)
Mayo Clinic
"Extremely clean, very pleasant hotel. It was a stressful visit to Mayo Clinic this was a very relaxing hotel to come back to after days of various dr visits."

Reviewed on May 3, 2024

EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
The price is $129 per night from May 6 to May 7
$129
per night
May 6 - May 7
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
7.4/10 Good! (1,192 reviews)
"The staff was very helpful and friendly, very convenient to the Mayo clinic."

Reviewed on May 1, 2024

Kahler Inn and Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3.5 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $111 per night from May 22 to May 23
$111
per night
May 22 - May 23
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (530 reviews)
"There was nothing to dislike really. This was the first time that I stayed at the Hyatt House while having to be at the Mayo Clinic. I plan to stay only at that hotel for future trips to the clinic. I was impressed."

Reviewed on May 3, 2024

Hyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
The price is $120 per night from May 19 to May 20
$120
per night
May 19 - May 20
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (529 reviews)
"Good location. I took an art workshop in town so this was a convenient location for my class. Room was small but well appointed. Some classmates also stayed at this hotel and they were on a noisy lower floor. Walls are thin so depending on the location of your room, it might be noisy."

Reviewed on May 1, 2024

Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
401 6th St Sw, Rochester, MN
  • 8 min walk from Mayo Clinic
The price is $123 per night from May 6 to May 7
$123
per night
May 6 - May 7
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8/10 Very Good! (1,000 reviews)
"Perfect location for Mayo visits, very clean and spacious room. Well worth the money."

Reviewed on May 2, 2024

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
The price is $86 per night from May 19 to May 20
$86
per night
May 19 - May 20
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,002 reviews)
"Room was okay. But it seemed like a lot of shady people around. We didn’t feel safe."

Reviewed on Apr 26, 2024

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 out of 5
1755 S Broadway, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $88 per night from May 25 to May 26
$88
per night
May 25 - May 26
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,005 reviews)
"The breakfast was horrible. Fake eggs and horrible chicken sausages"

Reviewed on May 4, 2024

Hampton Inn Rochester-South
Aspen Select
Aspen Select
3.5 out of 5
1215 2nd St SW, Rochester, MN
  • 21 min walk from Mayo Clinic
The price is $112 per night from May 6 to May 7
$112
per night
May 6 - May 7
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,007 reviews)
Makes A Hospital Visit Simple
"We were down to the Mayo Clinic St Mary’s campus in Rochester Minnesota for surgery. This hotel is literally right across the street. This made it easy to get back and forth during our 2 days. A bonus was free parking. The Canadian Honker restaurant is also right next door with simple homemade food ..."

Reviewed on May 4, 2024

Aspen Select
TownePlace Suites by Marriott Rochester Mayo Clinic Area
TownePlace Suites by Marriott Rochester Mayo Clinic Area
3 out of 5
601 2ND STREET SW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $127 per night from May 10 to May 11
$127
per night
May 10 - May 11
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.6/10 Exceptional! (271 reviews)
"I appreciate the convenience of the location to Mayo Clinic. Staff were accommodating and friendly. Beds are very comfortable."

Reviewed on Apr 30, 2024

TownePlace Suites by Marriott Rochester Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in St. Charles

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in St. Charles.

Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of St. Charles’s 495 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% St. Charles hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in St. Charles. No matter your reason for visiting St. Charles, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About St. Charles hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in St. Charles for as low as $63.

How many hotels are there in St. Charles?

With over 495 hotels in St. Charles, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.

How to find cheap car rentals in St. Charles?

Finding a cheap car rental deal in St. Charles is as easy as scoring cheap hotels in St. Charles. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to St. Charles now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to St. Charles right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.