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5 Star Hotels in Colon

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Tonight Jun 16 - Jun 17Next weekend Jun 21 - Jun 23

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Featured 5 Star Colon Hotels

Hotel Riu Plaza Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $103 per night from Jun 17 to Jun 18
$103
per night
Jun 17 - Jun 18
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 3 restaurants, and 24-hour room service. Our guests praise the breakfast and the pool in our ...
Hotel Riu Plaza Panama
Waldorf Astoria Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $172 per night from Jul 7 to Jul 8
$172
per night
Jul 7 - Jul 8
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Waldorf Astoria Panama
W Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $233 per night from Jul 3 to Jul 4
$233
per night
Jul 3 - Jul 4
Stay at this 5-star luxury hotel in Panama City. Enjoy 2 restaurants, 3 spa tubs, and 2 bars/lounges. Our guests praise the breakfast and the pool in our reviews. ...
W Panama
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JW Marriott Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $260 per night from Jul 11 to Jul 12
$260
per night
Jul 11 - Jul 12
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our ...
JW Marriott Panama
Hilton Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $172 per night from Jul 12 to Jul 13
$172
per night
Jul 12 - Jul 13
Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the pool and the helpful ...
Hilton Panama
Sofitel Legend Casco Viejo, Panama City
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $292 per night from Jun 21 to Jun 22
$292
per night
Jun 21 - Jun 22
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the breakfast and the pool in our ...
Sofitel Legend Casco Viejo, Panama City
The Westin Playa Bonita Panama
5 out of 5
  • 2 hours drive from Colon Free Zone
The price is $175 per night from Jun 26 to Jun 27
$175
per night
Jun 26 - Jun 27
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
The Westin Playa Bonita Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $255 per night from Jul 13 to Jul 14
$255
per night
Jul 13 - Jul 14
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff ...
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Bristol Panama, a Registry Collection Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Colon Free Zone
The price is $202 per night from Jun 22 to Jun 23
$202
per night
Jun 22 - Jun 23
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the breakfast and the restaurant ...
Bristol Panama, a Registry Collection Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Colon

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Colon.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Colon for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $103.

  • Amenities: Colon skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Colon—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Colon your way.