Search Cheap Flights to
Middlesboro

Photo by Alexis Wyrick

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Middlesboro Flights as Low as $198

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

United
Sat, May 17 - Tue, Jun 3
ORD
O'Hare Intl.
TYS
McGhee Tyson
$198 Roundtrip, found 8 hours ago
$198
Roundtrip
found 8 hours ago
Select United flight, departing Sat, May 17 from O'Hare Intl. to McGhee Tyson, returning Tue, Jun 3, priced at $198 found 8 hours ago
Frontier Airlines
Thu, Jul 10 - Sun, Jul 13
DEN
Denver Intl.
TYS
McGhee Tyson
$202 Roundtrip, found 1 day ago
$202
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Jul 10 from Denver Intl. to McGhee Tyson, returning Sun, Jul 13, priced at $202 found 1 day ago
Bargain Flight
Sat, Jul 26 - Wed, Jul 30
ROC
Greater Rochester Intl.
TYS
McGhee Tyson
$209 Roundtrip, found 9 hours ago
$209
Roundtrip
found 9 hours ago
Select Bargain Flight flight, departing Sat, Jul 26 from Greater Rochester Intl. to McGhee Tyson, returning Wed, Jul 30, priced at $209 found 9 hours ago
Bargain Flight
Fri, May 2 - Sun, May 4
ORF
Norfolk Intl.
TYS
McGhee Tyson
$218 Roundtrip, found 10 hours ago
$218
Roundtrip
found 10 hours ago
Select Bargain Flight flight, departing Fri, May 2 from Norfolk Intl. to McGhee Tyson, returning Sun, May 4, priced at $218 found 10 hours ago
United
Tue, May 13 - Tue, May 20
IAH
George Bush Intercontinental
TYS
McGhee Tyson
$222 Roundtrip, found 15 hours ago
$222
Roundtrip
found 15 hours ago
Select United flight, departing Tue, May 13 from George Bush Intercontinental to McGhee Tyson, returning Tue, May 20, priced at $222 found 15 hours ago
Delta
Wed, Oct 8 - Tue, Oct 14
LGA
LaGuardia
TYS
McGhee Tyson
$227 Roundtrip, found 6 days ago
$227
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Oct 8 from LaGuardia to McGhee Tyson, returning Tue, Oct 14, priced at $227 found 6 days ago
Delta
Sat, May 10 - Tue, May 13
RDU
Raleigh - Durham Intl.
TYS
McGhee Tyson
$234 Roundtrip, found 16 hours ago
$234
Roundtrip
found 16 hours ago
Select Delta flight, departing Sat, May 10 from Raleigh - Durham Intl. to McGhee Tyson, returning Tue, May 13, priced at $234 found 16 hours ago
Delta
Mon, Oct 6 - Sat, Oct 11
SYR
Hancock Intl.
TYS
McGhee Tyson
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Oct 6 from Hancock Intl. to McGhee Tyson, returning Sat, Oct 11, priced at $249 found 1 day ago
American Airlines
Wed, Aug 6 - Sat, Aug 9
SJC
Norman Y. Mineta San Jose Intl.
TYS
McGhee Tyson
$251 Roundtrip, found 7 hours ago
$251
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Aug 6 from Norman Y. Mineta San Jose Intl. to McGhee Tyson, returning Sat, Aug 9, priced at $251 found 7 hours ago
Delta
Wed, Jul 9 - Tue, Jul 15
PDX
Portland Intl.
TYS
McGhee Tyson
$251 Roundtrip, found 14 hours ago
$251
Roundtrip
found 14 hours ago
Select Delta flight, departing Wed, Jul 9 from Portland Intl. to McGhee Tyson, returning Tue, Jul 15, priced at $251 found 14 hours ago
American Airlines
Tue, Jun 17 - Sat, Jun 21
FLL
Fort Lauderdale - Hollywood Intl.
TYS
McGhee Tyson
$253 Roundtrip, found 20 hours ago
$253
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Jun 17 from Fort Lauderdale - Hollywood Intl. to McGhee Tyson, returning Sat, Jun 21, priced at $253 found 20 hours ago
Delta
Tue, May 13 - Tue, May 20
BUF
Buffalo Niagara Intl.
TYS
McGhee Tyson
$256 Roundtrip, found 12 hours ago
$256
Roundtrip
found 12 hours ago
Select Delta flight, departing Tue, May 13 from Buffalo Niagara Intl. to McGhee Tyson, returning Tue, May 20, priced at $256 found 12 hours ago
Delta
Mon, Oct 6 - Sat, Oct 11
BGM
Greater Binghamton
TYS
McGhee Tyson
$309 Roundtrip, found 1 day ago
$309
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Oct 6 from Greater Binghamton to McGhee Tyson, returning Sat, Oct 11, priced at $309 found 1 day ago
American Airlines
Wed, May 14 - Tue, May 20
YYZ
Pearson Intl.
TYS
McGhee Tyson
$340 Roundtrip, found 15 hours ago
$340
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, May 14 from Pearson Intl. to McGhee Tyson, returning Tue, May 20, priced at $340 found 15 hours ago
Delta
Sat, Aug 23 - Tue, Aug 26
DAL
Love Field
TYS
McGhee Tyson
$357 Roundtrip, found 2 days ago
$357
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Aug 23 from Love Field to McGhee Tyson, returning Tue, Aug 26, priced at $357 found 2 days ago
Delta
Sat, Jun 21 - Sun, Jun 22
ATL
Hartsfield-Jackson Atlanta Intl.
TYS
McGhee Tyson
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Jun 21 from Hartsfield-Jackson Atlanta Intl. to McGhee Tyson, returning Sun, Jun 22, priced at $359 found 1 day ago

Cheap Flights to Middlesboro

Fall in love at first flight with your vacation to Middlesboro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Middlesboro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Middlesboro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Middlesboro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Middlesboro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the TYS airport.

What is the cheapest month to fly to Middlesboro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Middlesboro are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Middlesboro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Middlesboro.

What airport is best to fly into Middlesboro?

When you’re planning your trip to Middlesboro, convenience is the name of the game. Luckily, Middlesboro McGhee Tyson Airport is nearby so you can deplane and get going on checking off everything on your Middlesboro must-do list.

How much are flights to Middlesboro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Middlesboro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $198, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Middlesboro?

The trick to saving a stack of cash on your flight to Middlesboro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $198 right now, why wait?

Middlesboro Flight Information
Destination airport
McGhee Tyson
Destination airport IATA code
TYS
Roundtrip price
$197

Last Minute Hotel Deals in Middlesboro

Sleep Inn & Suites
Sleep Inn & Suites
2.5 out of 5
1260 N, 12th Street, Middlesboro, KY
The price is $110 per night from May 11 to May 12
$110
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (707 reviews)
"X"

Reviewed on Apr 24, 2025

Sleep Inn & Suites
Holiday Inn Express Middlesboro by IHG
Holiday Inn Express Middlesboro by IHG
2.5 out of 5
1252 N 12th St, Middlesboro, KY
The price is $122 per night from May 11 to May 12
$122
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (649 reviews)
"Our room was clean and ready when we arrived. The staff were pleasant and very helpful!"

Reviewed on Apr 23, 2025

Holiday Inn Express Middlesboro by IHG
Econo Lodge Middlesboro
Econo Lodge Middlesboro
2 out of 5
1623 Cumberland Avenue, Middlesboro, KY
The price is $98 per night from May 11 to May 12
$98
includes taxes & fees
May 11 - May 12
Stay at this motel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
6.8/10 (374 reviews)
"Nothing fancy but clean and updated on the inside"

Reviewed on Apr 22, 2025

Econo Lodge Middlesboro
Boone Trail Inn
Boone Trail Inn
2 out of 5
2105 US HIGHWAY 25 E, Middlesboro, KY
The price is $91 per night from May 1 to May 2
$91
includes taxes & fees
May 1 - May 2
Stay at this motel in Middlesboro. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...
7/10 Good! (89 reviews)
"Its convenient. & they are remodeling so the rooms are really nice."

Reviewed on Apr 13, 2025

Boone Trail Inn
Holiday Inn Express Williamsburg by IHG
Holiday Inn Express Williamsburg by IHG
2.5 out of 5
56 West Highway 92, Williamsburg, KY
The price is $141 per night from May 18 to May 19
$141
includes taxes & fees
May 18 - May 19
Stay at this hotel in Williamsburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (941 reviews)
"Very nice hotel."

Reviewed on Apr 20, 2025

Holiday Inn Express Williamsburg by IHG
Days Inn by Wyndham Jellico - Tennessee State Line
Days Inn by Wyndham Jellico - Tennessee State Line
2 out of 5
1417 5th Street, Jellico, TN
The price is $75 per night from May 5 to May 6
$75
includes taxes & fees
May 5 - May 6
Book a stay at this spa hotel in Jellico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (937 reviews)
"The front desk receptionist that checked me in was very friendly and helpful. Every employee that I encountered was very nice."

Reviewed on Apr 26, 2025

Days Inn by Wyndham Jellico - Tennessee State Line
Pine Mountain State Resort Park
Pine Mountain State Resort Park
3 out of 5
1050 State Park Road, Pineville, KY
The price is $133 per night from May 1 to May 2
$133
includes taxes & fees
May 1 - May 2
Stay at this 3-star golf hotel in Pineville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (555 reviews)
"Mattress so,so,so hard and uncomfortable it felt like a board with a couple of blankets on top. Heard the people next door to us , they were so loud and it sounded like they were in our room the walls were so thin. But the area beautiful and such kind workers so accommodating."

Reviewed on Apr 13, 2025

Pine Mountain State Resort Park
Cumberland Gap Inn
Cumberland Gap Inn
2.5 out of 5
630 Brooklyn Street, Cumberland Gap, TN
Stay at this motel in Cumberland Gap. Enjoy free WiFi, free parking, and balconies or patios. Popular attractions Cumberland Gap National Historical Park and ...
7.8/10 Good! (565 reviews)
The good & the not so good.
"The good points were the location, the friendly welcome at the desk, and the cleanliness of the room, linen, and towels. I will say, the laminate floor appeared to have been mopped with dirty water as it had a tacky film that left our socks dirty. The shower water was just barely warm when on full ..."

Reviewed on Apr 26, 2025

Get rates
Cumberland Gap Inn
See all 320 properties in Middlesboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.