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Hotels in Eastern Panama

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Choose from 173 Eastern Panama Hotel Deals

Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
  • 29 min walk from Isla Mamey
Stay at this hotel in Puerto Lindo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located ...
9.6/10 Exceptional! (10 reviews)
Beautiful tranquility in nature, amazing staff

Reviewed on Nov 23, 2025

Ranchos de Chalia
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
  • 6 min drive from Isla Mamey
Book a stay at this beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National ...
4.6/10 (3 reviews)
Although I gave this hotel a medium rating I enjoyed myself. This is a rough almost close to camping hotel. I must have not seen the message about bringing soap wash clothes, hand towel, tissue actually everything. The water does not get cold and there was a party set up just outside the window lasting ...

Reviewed on Sep 19, 2025

HOTEL ISLA GRANDE
Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
  • 7 min drive from Isla Mamey
Book a stay at this luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park ...
10/10 Exceptional! (3 reviews)
Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special.

Reviewed on Sep 5, 2025

Ordovician Beach Resort
Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale Cacique Provincia de Colón
  • 25 min walk from Isla Mamey
Book a stay at this beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park ...
10/10 Exceptional! (9 reviews)
All was good

Reviewed on Jul 14, 2025

Ciel y Miel
Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
  • 7 min drive from Isla Mamey
Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located ...
10/10 Exceptional! (2 reviews)
It was old, quaint interesting, would recommend

Reviewed on Sep 5, 2025

Hotel Cocotal
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this property in San Blas Islands. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Porvenir Museum and Isla Chichime are ...
Cocoloco - Catamaran Lagoon 52F SAN BLAS
 San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo ...
San Blas Paradise Private Cabins on Shipwreck Island - meals included
Konsenda San Blas

Konsenda San Blas

2 out of 5
Llano Cartí Km 11 El Llano Panamá Province
  • 2 hours drive from Isla Mamey
Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden.
10/10 Exceptional! (1 review)
wonderful eco lodge in the forest. Easy to reach by car, just on the main road. Paths to walk, excellent meals. A very good option if you need to relax before and after visiting Sab Blas, but worth the trip on its own, beautiful landscape.

Reviewed on Mar 6, 2025

Konsenda San Blas
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ...
Private Ocean-Front Cabin with private bathroom on San Blas Island
Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

2 out of 5
9.542876, -78.899058 Narganá San Blas
  • 2 hours drive from Isla Mamey
Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Chichime ...
7/10 Good! (6 reviews)
Very nice. And I liked the food

Reviewed on Aug 14, 2025

Private Over the Water Cabin on San Blas Island
Private Bedroom on Paradise San Blas Island

Private Bedroom on Paradise San Blas Island

2.5 out of 5
Isla Yansailadup Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this guesthouse in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Museum of the ...
10/10 Exceptional! (1 review)
Paradise
Don’t go expecting a resort and you will thoroughly enjoy yourself. The Guna that run the island are all warm, friendly, helpful. Great snorkelling tours and beautiful clean water. The accommodations are very simple but comfortable. Shared bathroom that was kept very clean. A great place to get away ...

Reviewed on Jan 13, 2023

Private Bedroom on Paradise San Blas Island
Cabins in Asserya Island - San Blas paradise - meals included

Cabins in Asserya Island - San Blas paradise - meals included

2 out of 5
Aroma Island (Isla Anzuelo) Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this hotel in San Blas Islands. Enjoy free breakfast, a marina, and an airport shuttle (surcharge). Popular attractions Museum and Isla Chichime are ...
Cabins in Asserya Island - San Blas paradise - meals included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Eastern Panama

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Frequently Asked Questions About Eastern Panama hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Eastern Panama?

With over 173 hotels in Eastern Panama, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $55.

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