Search Cheap Flights to
Serena

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Serena Flights as Low as $56

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Aug 12 - Tue, Aug 18
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$56 Roundtrip, found 19 hours ago
$56
Roundtrip
found 19 hours ago
Select Frontier Airlines flight, departing Wed, Aug 12 from George Bush Intercontinental to O'Hare Intl., returning Tue, Aug 18, priced at $56 found 19 hours ago
Frontier Airlines
Tue, Jun 9 - Wed, Jun 17
ATL
Hartsfield-Jackson Atlanta Intl.
MDW
Midway Intl.
$66 Roundtrip, found 2 hours ago
$66
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, Jun 9 from Hartsfield-Jackson Atlanta Intl. to Midway Intl., returning Wed, Jun 17, priced at $66 found 2 hours ago
Frontier Airlines
Tue, Jun 9 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
ORD
O'Hare Intl.
$66 Roundtrip, found 2 hours ago
$66
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, Jun 9 from Hartsfield-Jackson Atlanta Intl. to O'Hare Intl., returning Tue, Jun 16, priced at $66 found 2 hours ago
Frontier Airlines
Tue, Jun 2 - Tue, Jun 2
ATL
Hartsfield-Jackson Atlanta Intl.
ORD
O'Hare Intl.
$68 Roundtrip, found 18 hours ago
$68
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Hartsfield-Jackson Atlanta Intl. to O'Hare Intl., returning Tue, Jun 2, priced at $68 found 18 hours ago
Frontier Airlines
Wed, May 27 - Tue, Jun 2
ATL
Hartsfield-Jackson Atlanta Intl.
ORD
O'Hare Intl.
$68 Roundtrip, found 4 hours ago
$68
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Wed, May 27 from Hartsfield-Jackson Atlanta Intl. to O'Hare Intl., returning Tue, Jun 2, priced at $68 found 4 hours ago
United
Wed, Aug 12 - Tue, Aug 18
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$169 Roundtrip, found 19 hours ago
$169
Roundtrip
found 19 hours ago
Select United flight, departing Wed, Aug 12 from George Bush Intercontinental to O'Hare Intl., returning Tue, Aug 18, priced at $169 found 19 hours ago
American Airlines
Tue, Jul 28 - Tue, Aug 4
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$169 Roundtrip, found 3 hours ago
$169
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 28 from George Bush Intercontinental to O'Hare Intl., returning Tue, Aug 4, priced at $169 found 3 hours ago
Delta
Tue, Jun 16 - Wed, Jul 1
IAH
George Bush Intercontinental
MDW
Midway Intl.
$197 Roundtrip, found 17 hours ago
$197
Roundtrip
found 17 hours ago
Select Delta flight, departing Tue, Jun 16 from George Bush Intercontinental to Midway Intl., returning Wed, Jul 1, priced at $197 found 17 hours ago
Delta
Tue, Jul 28 - Tue, Aug 4
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$197 Roundtrip, found 3 hours ago
$197
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Jul 28 from George Bush Intercontinental to O'Hare Intl., returning Tue, Aug 4, priced at $197 found 3 hours ago
JetBlue Airways
Tue, Aug 18 - Tue, Sep 1
ATL
Hartsfield-Jackson Atlanta Intl.
ORD
O'Hare Intl.
$287 Roundtrip, found 5 hours ago
$287
Roundtrip
found 5 hours ago
Select JetBlue Airways flight, departing Tue, Aug 18 from Hartsfield-Jackson Atlanta Intl. to O'Hare Intl., returning Tue, Sep 1, priced at $287 found 5 hours ago
American Airlines
Fri, May 29 - Sat, Aug 1
IAH
George Bush Intercontinental
PIA
Greater Peoria Regional
$305 Roundtrip, found 5 hours ago
$305
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Fri, May 29 from George Bush Intercontinental to Greater Peoria Regional, returning Sat, Aug 1, priced at $305 found 5 hours ago
American Airlines
Fri, May 29 - Sat, Aug 1
IAH
George Bush Intercontinental
RFD
Greater Rockford
$318 Roundtrip, found 2 days ago
$318
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, May 29 from George Bush Intercontinental to Greater Rockford, returning Sat, Aug 1, priced at $318 found 2 days ago
Bargain Flight
Wed, May 20 - Thu, May 21
ATL
Hartsfield-Jackson Atlanta Intl.
PIA
Greater Peoria Regional
$320 Roundtrip, found 2 hours ago
$320
Roundtrip
found 2 hours ago
Select Bargain Flight flight, departing Wed, May 20 from Hartsfield-Jackson Atlanta Intl. to Greater Peoria Regional, returning Thu, May 21, priced at $320 found 2 hours ago
American Airlines
Sat, Jun 20 - Tue, Jun 23
ATL
Hartsfield-Jackson Atlanta Intl.
RFD
Greater Rockford
$331 Roundtrip, found 1 day ago
$331
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jun 20 from Hartsfield-Jackson Atlanta Intl. to Greater Rockford, returning Tue, Jun 23, priced at $331 found 1 day ago
Delta
Fri, Jun 12 - Sat, Jun 27
ATL
Hartsfield-Jackson Atlanta Intl.
BMI
Central Illinois Regional
$399 Roundtrip, found 5 hours ago
$399
Roundtrip
found 5 hours ago
Select Delta flight, departing Fri, Jun 12 from Hartsfield-Jackson Atlanta Intl. to Central Illinois Regional, returning Sat, Jun 27, priced at $399 found 5 hours ago
Alaska Airlines
Wed, Jun 24 - Tue, Jul 7
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$744 Roundtrip, found 1 day ago
$744
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Wed, Jun 24 from George Bush Intercontinental to O'Hare Intl., returning Tue, Jul 7, priced at $744 found 1 day ago

Cheap Flights to Serena

Fall in love at first flight with your vacation to Serena by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Serena on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Serena, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Serena

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Serena with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the VYS airport.

What is the cheapest month to fly to Serena?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Serena are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Serena?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Serena.

What airport is best to fly into Serena?

When you’re planning your trip to Serena, convenience is the name of the game. Luckily, Serena Dupage Airport is nearby so you can deplane and get going on checking off everything on your Serena must-do list.

How much are flights to Serena?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Serena on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $56, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Serena?

The trick to saving a stack of cash on your flight to Serena? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $56 right now, why wait?

Serena Flight Information
Destination airport
O'Hare Intl.
Destination airport IATA code
ORD
Roundtrip price
$131

Last Minute Hotel Deals in Serena

Grand Bear Resort at Starved Rock

Grand Bear Resort at Starved Rock

3 out of 5
2643 IL-178 Utica IL
Book a stay at this golf hotel in Utica. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.2/10 Good! (1,016 reviews)
The website said water park would be open May 8 and still wasn’t open on May 9 wasted my money for my kids birthday and didn’t even get to swim. What a dirty place

Reviewed on May 10, 2026

Get rates
Grand Bear Resort at Starved Rock
Postcard Cabins Starved Rock, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Starved Rock, Outdoor Collection by Marriott Bonvoy

2 out of 5
1879 N 2703rd Rd Ottawa IL
Stay at this cabin in Ottawa. Enjoy free parking, patios, and climate control. Popular attractions Tangled Roots Brewing Company - The Lone Buffalo and Washington ...
9.8/10 Exceptional! (189 reviews)
All I can say is very peaceful & relaxing! I had the best sleep ever! I’m a very satisfied customer!

Reviewed on May 4, 2026

Get rates
Postcard Cabins Starved Rock, Outdoor Collection by Marriott Bonvoy
Days Inn & Suites by Wyndham Morris/I-80

Days Inn & Suites by Wyndham Morris/I-80

2 out of 5
80 Hampton Road Morris IL
Book a stay at this business-friendly hotel in Morris. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the helpful staff and ...
7/10 Good! (793 reviews)
Continental breakfast average. Front desk clerk Michelle was always friendly and helpful. There are 2 new 100 gallon water, still their shipping containers, sitting in the hallway. I was there for 3 weeks and there was no movement to install the heaters. Hotel location was great for me. Close to ...

Reviewed on Apr 25, 2026

Get rates
Days Inn & Suites by Wyndham Morris/I-80
Days Inn by Wyndham Oglesby/ Starved Rock

Days Inn by Wyndham Oglesby/ Starved Rock

2 out of 5
120 N Lewis Ave Oglesby IL
Book a stay at this business-friendly hotel in Oglesby. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,003 reviews)
Very clean and friendly staff

Reviewed on May 11, 2026

Get rates
Days Inn by Wyndham Oglesby/ Starved Rock
Super 8 by Wyndham Ottawa Starved Rock

Super 8 by Wyndham Ottawa Starved Rock

2 out of 5
500 East Etna Rd. Ottawa IL
Book a stay at this business-friendly hotel in Ottawa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy rooms ...
8.6/10 Excellent! (1,006 reviews)
Bathroom shower floor dirty and grimy,room dirty smells of curry

Reviewed on May 10, 2026

Get rates
Super 8 by Wyndham Ottawa Starved Rock
Hampton Inn Yorkville

Hampton Inn Yorkville

2.5 out of 5
310 East Countryside Parkway Yorkville IL
Book a stay at this business-friendly hotel in Yorkville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (946 reviews)
The hotel is fairly new, and was very clean. The room was large, and beds comfortable. Would definitely stay there again.

Reviewed on May 11, 2026

Get rates
Hampton Inn Yorkville
Holiday Inn Express & Suites Yorkville by IHG

Holiday Inn Express & Suites Yorkville by IHG

2.5 out of 5
577 E KENDALL DRIVE Yorkville IL
Book a stay at this spa hotel in Yorkville. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (691 reviews)
This hotel was ok but not great for the price. I paid 200$ a night for an ok nothing fantastic stay

Reviewed on May 4, 2026

Get rates
Holiday Inn Express & Suites Yorkville by IHG
Best Western Oglesby Inn

Best Western Oglesby Inn

2.5 out of 5
900 Holiday Street Oglesby IL
Book a stay at this business-friendly hotel in Oglesby. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.2/10 Very Good! (1,006 reviews)
Everything was clean

Reviewed on May 7, 2026

Get rates
Best Western Oglesby Inn
See all 347 properties in Serena
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.