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O Brien

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O Brien Flights as Low as $201

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

United
Mon, Aug 25 - Thu, Aug 28
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$201 Roundtrip, found 15 hours ago
$201
Roundtrip
found 15 hours ago
Select United flight, departing Mon, Aug 25 from George Bush Intercontinental to Jacksonville Intl., returning Thu, Aug 28, priced at $201 found 15 hours ago
American Airlines
Mon, Aug 25 - Thu, Aug 28
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$210 Roundtrip, found 15 hours ago
$210
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Mon, Aug 25 from George Bush Intercontinental to Jacksonville Intl., returning Thu, Aug 28, priced at $210 found 15 hours ago
American Airlines
Mon, Aug 25 - Thu, Aug 28
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$220 Roundtrip, found 15 hours ago
$220
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Mon, Aug 25 from George Bush Intercontinental to Jacksonville Intl., returning Thu, Aug 28, priced at $220 found 15 hours ago
Delta
Mon, Aug 25 - Thu, Aug 28
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$220 Roundtrip, found 15 hours ago
$220
Roundtrip
found 15 hours ago
Select Delta flight, departing Mon, Aug 25 from George Bush Intercontinental to Jacksonville Intl., returning Thu, Aug 28, priced at $220 found 15 hours ago
United
Tue, Aug 26 - Sat, Aug 30
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$228 Roundtrip, found 5 days ago
$228
Roundtrip
found 5 days ago
Select United flight, departing Tue, Aug 26 from George Bush Intercontinental to Jacksonville Intl., returning Sat, Aug 30, priced at $228 found 5 days ago
Bargain Flight
Thu, Dec 11 - Tue, Dec 16
CLE
Hopkins Intl.
JAX
Jacksonville Intl.
$231 Roundtrip, found 1 hour ago
$231
Roundtrip
found 1 hour ago
Select Bargain Flight flight, departing Thu, Dec 11 from Hopkins Intl. to Jacksonville Intl., returning Tue, Dec 16, priced at $231 found 1 hour ago
United
Mon, Aug 25 - Thu, Aug 28
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$233 Roundtrip, found 15 hours ago
$233
Roundtrip
found 15 hours ago
Select United flight, departing Mon, Aug 25 from George Bush Intercontinental to Jacksonville Intl., returning Thu, Aug 28, priced at $233 found 15 hours ago
Delta
Tue, Nov 11 - Sat, Nov 15
CLE
Hopkins Intl.
TLH
Tallahassee Intl.
$271 Roundtrip, found 9 hours ago
$271
Roundtrip
found 9 hours ago
Select Delta flight, departing Tue, Nov 11 from Hopkins Intl. to Tallahassee Intl., returning Sat, Nov 15, priced at $271 found 9 hours ago
Delta
Wed, Jul 9 - Tue, Jul 15
CLE
Hopkins Intl.
GNV
Gainesville Regional
$337 Roundtrip, found 1 day ago
$337
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Jul 9 from Hopkins Intl. to Gainesville Regional, returning Tue, Jul 15, priced at $337 found 1 day ago
JetBlue Airways
Wed, Jul 23 - Tue, Jul 29
CLE
Hopkins Intl.
JAX
Jacksonville Intl.
$367 Roundtrip, found 21 hours ago
$367
Roundtrip
found 21 hours ago
Select JetBlue Airways flight, departing Wed, Jul 23 from Hopkins Intl. to Jacksonville Intl., returning Tue, Jul 29, priced at $367 found 21 hours ago
American Airlines
Tue, Jul 22 - Fri, Aug 1
IAH
George Bush Intercontinental
GNV
Gainesville Regional
$398 Roundtrip, found 14 hours ago
$398
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Tue, Jul 22 from George Bush Intercontinental to Gainesville Regional, returning Fri, Aug 1, priced at $398 found 14 hours ago
Delta
Tue, Dec 9 - Mon, Jan 12
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,123 Roundtrip, found 22 hours ago
$1,123
Roundtrip
found 22 hours ago
Select Delta flight, departing Tue, Dec 9 from O.R. Tambo Intl. to Gainesville Regional, returning Mon, Jan 12, priced at $1,123 found 22 hours ago
Virgin Atlantic
Mon, Dec 1 - Tue, Jan 6
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,158 Roundtrip, just found
$1,158
Roundtrip
just found
Select Virgin Atlantic flight, departing Mon, Dec 1 from O.R. Tambo Intl. to Gainesville Regional, returning Tue, Jan 6, priced at $1,158 just found
KLM
Tue, Dec 9 - Tue, Jan 13
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,199 Roundtrip, found 22 hours ago
$1,199
Roundtrip
found 22 hours ago
Select KLM flight, departing Tue, Dec 9 from O.R. Tambo Intl. to Gainesville Regional, returning Tue, Jan 13, priced at $1,199 found 22 hours ago
Air France
Thu, Dec 11 - Thu, Jan 15
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,360 Roundtrip, found 22 hours ago
$1,360
Roundtrip
found 22 hours ago
Select Air France flight, departing Thu, Dec 11 from O.R. Tambo Intl. to Gainesville Regional, returning Thu, Jan 15, priced at $1,360 found 22 hours ago
Qatar Airways
Tue, Dec 9 - Tue, Jan 13
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$2,074 Roundtrip, found 22 hours ago
$2,074
Roundtrip
found 22 hours ago
Select Qatar Airways flight, departing Tue, Dec 9 from O.R. Tambo Intl. to Gainesville Regional, returning Tue, Jan 13, priced at $2,074 found 22 hours ago

Cheap Flights to O Brien

Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to O Brien

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the null airport.

What is the cheapest month to fly to O Brien?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to O Brien?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to O Brien.

What airport is best to fly into O Brien?

When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.

How much are flights to O Brien?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $201, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to O Brien?

The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $201 right now, why wait?

O Brien Flight Information
Destination airport
Jacksonville Intl.
Destination airport IATA code
JAX
Roundtrip price
$68

Last Minute Hotel Deals in O Brien

La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
2.5 out of 5
165NW CALI DRIVE, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,001 reviews)
"The staff was very polite, considerate and helpful. Oh yeah and friendly. I normally stay at the COMFORT INN, but Laquinta Inn has won me over. I am looking forward to my next visit/ stay."

Reviewed on Jul 1, 2025

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La Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
Stay at this 3.5-star business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,005 reviews)
"Nice quiet hotel. Good breakfast options!"

Reviewed on Jul 3, 2025

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Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Best Western Plus Lake City
Best Western Plus Lake City
2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,002 reviews)
"Very clean and well-kept"

Reviewed on Jul 6, 2025

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Best Western Plus Lake City
Comfort Suites Lake City
Comfort Suites Lake City
2.5 out of 5
3690 W Us Highway 90, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,004 reviews)
"Great experience"

Reviewed on Jul 4, 2025

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Comfort Suites Lake City
Tru by Hilton Lake City
Tru by Hilton Lake City
2.5 out of 5
284 NW Centurion Court, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,001 reviews)
"Very nice"

Reviewed on Jun 30, 2025

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Tru by Hilton Lake City
Postcard Cabins Gilchrist Springs
Postcard Cabins Gilchrist Springs
2 out of 5
1699 NE Co Rd 337, High Springs, FL
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ginnie Spring and Ruth B. Kirby Gilchrist Blue Springs ...
10/10 Exceptional! (41 reviews)
"Wonderful, romantic getaway! Very clean and accommodating. Grocery store is 15 min in town (high springs) close to several springs and parks! Property is nice and quiet! We had a wasp infestation at our door entry and the response time was fantastic! Sprayed the area and let us keep a can just in ..."

Reviewed on Jun 29, 2025

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Postcard Cabins Gilchrist Springs
Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
3 out of 5
3004 West US HWY 90, Lake City, FL
Stay at this 3-star business-friendly hotel in Lake City. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Regal UA Cinema 90 and ...
9.6/10 Exceptional! (105 reviews)
"Everything was good. Bed was big & comfy. Room was clean. We ended up booking a second night in a different room for a reason not related to the hotel. TP was your standard, thin TP. And the shower leaked, bad. I turned on the water and while i was getting ready to get in, water was pooling outside ..."

Reviewed on Jul 2, 2025

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Courtyard By Marriott Lake City
Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHG
3 out of 5
213 Sw Commerce Dr, Lake City, FL
Stay at this 3-star business-friendly hotel in Lake City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.4/10 Very Good! (1,000 reviews)
"Nice large room, clean, comfortable. Great customer service. Beth was awesome!"

Reviewed on Jun 11, 2025

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Holiday Inn & Suites Lake City by IHG
See all 328 properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.