Search Cheap Flights toO Brien
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O Brien Flights as Low as $160
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
Tue, Jun 10 - Mon, Jun 16
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$160 Roundtrip, found 1 day ago
$160
Roundtrip
found 1 day ago
Tue, Jun 10 - Mon, Jun 16
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$170 Roundtrip, found 1 day ago
$170
Roundtrip
found 1 day ago
Thu, Jun 5 - Sun, Jun 15
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$170 Roundtrip, found 20 hours ago
$170
Roundtrip
found 20 hours ago
Tue, Aug 5 - Mon, Aug 11
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$177 Roundtrip, found 2 hours ago
$177
Roundtrip
found 2 hours ago
Tue, Jun 10 - Mon, Jun 16
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$179 Roundtrip, found 1 day ago
$179
Roundtrip
found 1 day ago
Tue, Aug 5 - Fri, Aug 8
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$187 Roundtrip, found 2 hours ago
$187
Roundtrip
found 2 hours ago
Fri, Jun 6 - Tue, Jun 17
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$190 Roundtrip, found 19 hours ago
$190
Roundtrip
found 19 hours ago
Tue, Aug 5 - Wed, Aug 6
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$197 Roundtrip, found 2 hours ago
$197
Roundtrip
found 2 hours ago
Mon, Aug 4 - Fri, Aug 8
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$198 Roundtrip, found 2 hours ago
$198
Roundtrip
found 2 hours ago
Tue, Jun 10 - Mon, Jun 16
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$200 Roundtrip, found 1 day ago
$200
Roundtrip
found 1 day ago
Fri, Jul 4 - Wed, Jul 9
SYR
Hancock Intl.
JAX
Jacksonville Intl.
$212 Roundtrip, found 4 days ago
$212
Roundtrip
found 4 days ago
Wed, Jun 11 - Thu, Jun 12
CLE
Hopkins Intl.
JAX
Jacksonville Intl.
$252 Roundtrip, found 10 hours ago
$252
Roundtrip
found 10 hours ago
Wed, May 28 - Tue, Jun 3
CLE
Hopkins Intl.
TLH
Tallahassee Intl.
$275 Roundtrip, found 1 day ago
$275
Roundtrip
found 1 day ago
Sun, Jul 13 - Thu, Jul 17
SYR
Hancock Intl.
JAX
Jacksonville Intl.
$339 Roundtrip, found 5 days ago
$339
Roundtrip
found 5 days ago
Sat, Sep 6 - Sat, Sep 13
EWR
Newark Liberty Intl. Airport
TLH
Tallahassee Intl.
$377 Roundtrip, found 1 day ago
$377
Roundtrip
found 1 day ago
Sun, Jan 11 - Tue, Jan 13
SYR
Hancock Intl.
TLH
Tallahassee Intl.
$486 Roundtrip, found 1 day ago
$486
Roundtrip
found 1 day ago
Cheap Flights to O Brien
Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.
Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.
Frequently Asked Questions About flights to O Brien
Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.
So all you have to worry about is where you’re headed after the null airport.
What is the cheapest month to fly to O Brien?
Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in June, but when you book your flight on Hotwire, savings are always in season.
How many airlines fly to O Brien?
Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to O Brien.
What airport is best to fly into O Brien?
When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.
How much are flights to O Brien?
Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $160, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.
How to get cheap flights to O Brien?
The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $160 right now, why wait?
Destination airport | Tallahassee Intl. |
Destination airport IATA code | TLH |
Roundtrip price | $167 |
Last Minute Hotel Deals in O Brien
La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE, Lake City, FL
The price is $114 per night from May 7 to May 8
$114
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,017 reviews)
Satisfied guest
"We were very happy with the cleanliness and comfort of our room and the condition of the Fitness center. They did a good job with the breakfast.Our only disappointment was the size of the pool."
Reviewed on May 2, 2025
Courtyard By Marriott Lake City
3004 West US HWY 90, Lake City, FL
The price is $118 per night from May 11 to May 12
$118
includes taxes & fees
May 11 - May 12
Stay at this 3-star business-friendly hotel in Lake City. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Lake City Mall and Southside ...
9.6/10 Exceptional! (76 reviews)
"Excellent room, super clean and tidy"
Reviewed on May 4, 2025
Best Western Plus Lake City
350 SW Florida Gateway Dr, Lake City, FL
The price is $105 per night from May 11 to May 12
$105
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,006 reviews)
"Staff was amazing !! I did get a knock on the door twice and they woke me up! Seeing if I left at 11 am check out was at 12 pm But other then that was a great an amazing experience!!"
Reviewed on May 1, 2025
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD, Alachua, FL
The price is $141 per night from May 11 to May 12
$141
includes taxes & fees
May 11 - May 12
Stay at this 3.5-star business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
"No complain"
Reviewed on Apr 27, 2025
Postcard Cabins Gilchrist Springs
1699 NE Co Rd 337, High Springs, FL
The price is $176 per night from May 6 to May 7
$176
includes taxes & fees
May 6 - May 7
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ginnie Spring and Ruth B. Kirby Gilchrist Blue Springs ...
10/10 Exceptional! (20 reviews)
Excelente
"Una experiencia muy agradable y una verdadera conexión con la naturaleza."
Reviewed on May 3, 2025
Days Inn by Wyndham Lake City I-75
3144 West US Highway 90, Lake City, FL
The price is $76 per night from May 7 to May 8
$76
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free parking, and WiFi (surcharge). Our guests praise the helpful staff and the ...
7.2/10 Good! (1,002 reviews)
"Professional staff, clean hotel with modern upgrades. Price was good. Plenty of shopping and dining close by. Check in process was a breeze."
Reviewed on Apr 28, 2025
Tru by Hilton Lake City
284 NW Centurion Court, Lake City, FL
The price is $123 per night from May 11 to May 12
$123
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,002 reviews)
"Everything was wonderful"
Reviewed on Apr 30, 2025
Comfort Suites Lake City
3690 W Us Highway 90, Lake City, FL
The price is $114 per night from Jun 3 to Jun 4
$114
includes taxes & fees
Jun 3 - Jun 4
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"good"
Reviewed on May 3, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top O Brien Hotels
- Best Western Plus Lake City
- Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
- Days Inn by Wyndham Lake City I-75
- Tru by Hilton Lake City
- Comfort Suites Lake City
- Holiday Inn & Suites Lake City by IHG
- Americas Best Value Inn Lake City
- Quality Inn Lake City
- Fairfield Inn & Suites Lake City
- Holiday Inn Express Hotel & Suites LIVE OAK by IHG