Search Cheap Flights toO Brien
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O Brien Flights as Low as $268
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
Wed, Jul 23 - Sat, Jul 26
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$268 Roundtrip, found 16 hours ago
$268
Roundtrip
found 16 hours ago
Mon, Aug 25 - Thu, Aug 28
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$271 Roundtrip, found 6 days ago
$271
Roundtrip
found 6 days ago
Tue, Aug 26 - Sat, Aug 30
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$273 Roundtrip, found 5 days ago
$273
Roundtrip
found 5 days ago
Wed, Jul 16 - Sun, Jul 20
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$276 Roundtrip, found 6 days ago
$276
Roundtrip
found 6 days ago
Wed, Jul 23 - Sat, Jul 26
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$277 Roundtrip, found 16 hours ago
$277
Roundtrip
found 16 hours ago
Wed, Jul 23 - Sat, Jul 26
HOU
William P. Hobby
JAX
Jacksonville Intl.
$287 Roundtrip, found 16 hours ago
$287
Roundtrip
found 16 hours ago
Wed, Jul 23 - Sat, Jul 26
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$287 Roundtrip, found 16 hours ago
$287
Roundtrip
found 16 hours ago
Wed, Jul 23 - Sat, Jul 26
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$288 Roundtrip, found 16 hours ago
$288
Roundtrip
found 16 hours ago
Wed, Jul 23 - Sat, Jul 26
IAH
George Bush Intercontinental
JAX
Jacksonville Intl.
$288 Roundtrip, found 16 hours ago
$288
Roundtrip
found 16 hours ago
Tue, Jul 22 - Tue, Jul 29
HOU
William P. Hobby
GNV
Gainesville Regional
$343 Roundtrip, found 16 hours ago
$343
Roundtrip
found 16 hours ago
Wed, Jul 23 - Sat, Jul 26
IAH
George Bush Intercontinental
GNV
Gainesville Regional
$343 Roundtrip, found 16 hours ago
$343
Roundtrip
found 16 hours ago
Sun, Nov 30 - Sun, Jan 4
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,150 Roundtrip, found 2 days ago
$1,150
Roundtrip
found 2 days ago
Wed, Dec 3 - Wed, Jan 7
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,217 Roundtrip, found 1 day ago
$1,217
Roundtrip
found 1 day ago
Wed, Dec 3 - Wed, Jan 7
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,403 Roundtrip, found 1 day ago
$1,403
Roundtrip
found 1 day ago
Wed, Dec 3 - Wed, Jan 7
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$1,749 Roundtrip, found 1 day ago
$1,749
Roundtrip
found 1 day ago
Sun, Nov 30 - Sun, Jan 4
JNB
O.R. Tambo Intl.
GNV
Gainesville Regional
$2,356 Roundtrip, found 2 days ago
$2,356
Roundtrip
found 2 days ago
Cheap Flights to O Brien
Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.
Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.
Frequently Asked Questions About flights to O Brien
Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.
So all you have to worry about is where you’re headed after the null airport.
What is the cheapest month to fly to O Brien?
Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in July, but when you book your flight on Hotwire, savings are always in season.
How many airlines fly to O Brien?
Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to O Brien.
What airport is best to fly into O Brien?
When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.
How much are flights to O Brien?
Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $268, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.
How to get cheap flights to O Brien?
The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $268 right now, why wait?
Destination airport | Jacksonville Intl. |
Destination airport IATA code | JAX |
Roundtrip price | $268 |
Last Minute Hotel Deals in O Brien
La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,000 reviews)
"Very clean and comfortable"
Reviewed on Jun 19, 2025
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD, Alachua, FL
Stay at this 3.5-star business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
"Clean rooms and quiet"
Reviewed on Jun 17, 2025
Best Western Plus Lake City
350 SW Florida Gateway Dr, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,007 reviews)
"The beds were very comfortable and the breakfast was good. I had scrambled eggs with cheese and ham and a cinnamon streusel bread with strawberries and blueberries over the top of it . They had plenty of choices for breakfast. I also liked that they had an indoor pool even though we didn’t use it ..."
Reviewed on Jun 18, 2025
Tru by Hilton Lake City
284 NW Centurion Court, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,000 reviews)
"Easy overnight stay"
Reviewed on Jun 17, 2025
Holiday Inn Express Hotel & Suites LIVE OAK by IHG
6694 Us Highway 129, Live Oak, FL
Book a stay at this business-friendly hotel in Live Oak. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (705 reviews)
"Muy cerca de la carretera y con varios lugares alrededor donde poder comer. Excelente para hacer una parada y seguir viaje"
Reviewed on Jun 13, 2025
Postcard Cabins Gilchrist Springs
1699 NE Co Rd 337, High Springs, FL
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ginnie Spring and Ruth B. Kirby Gilchrist Blue Springs ...
9.8/10 Exceptional! (34 reviews)
Quiet, fun retreat!
"Fun, delightful little cabin filled with everything we needed for a wonderful 3 day stay. Close to the springs, and quiet and peaceful! Loved the extra touches such as s’more kit, firewood, and cellphone lockbox!"
Reviewed on Jun 19, 2025
Comfort Suites Lake City
3690 W Us Highway 90, Lake City, FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,001 reviews)
"Room was very large and spacious"
Reviewed on Jun 19, 2025
Courtyard By Marriott Lake City
3004 West US HWY 90, Lake City, FL
Stay at this 3-star business-friendly hotel in Lake City. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Regal UA Cinema 90 and ...
9.6/10 Exceptional! (96 reviews)
"Rooms were new and clean. Nice bistro area downstairs for coffee and some food options. Nice area to work on my laptop."
Reviewed on Jun 19, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top O Brien Hotels
- Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
- Best Western Plus Lake City
- Tru by Hilton Lake City
- Holiday Inn Express Hotel & Suites LIVE OAK by IHG
- Comfort Suites Lake City
- Baymont by Wyndham Lake City
- Hampton Inn & Suites Lake City
- Holiday Inn & Suites Lake City by IHG
- Days Inn by Wyndham Lake City I-75
- Days Inn by Wyndham Lake City I-10
- Fairfield Inn & Suites Lake City