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O Brien

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O Brien Flights as Low as $176

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Apr 8 - Thu, Apr 9
ATL
Hartsfield-Jackson Atlanta Intl.
JAX
Jacksonville Intl.
$176 Roundtrip, found 12 hours ago
$176
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Wed, Apr 8 from Hartsfield-Jackson Atlanta Intl. to Jacksonville Intl., returning Thu, Apr 9, priced at $176 found 12 hours ago
Frontier Airlines
Mon, Apr 27 - Sat, May 9
ATL
Hartsfield-Jackson Atlanta Intl.
JAX
Jacksonville Intl.
$180 Roundtrip, found 1 day ago
$180
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Apr 27 from Hartsfield-Jackson Atlanta Intl. to Jacksonville Intl., returning Sat, May 9, priced at $180 found 1 day ago
Frontier Airlines
Sun, Apr 26 - Tue, May 12
ATL
Hartsfield-Jackson Atlanta Intl.
JAX
Jacksonville Intl.
$183 Roundtrip, found 3 days ago
$183
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sun, Apr 26 from Hartsfield-Jackson Atlanta Intl. to Jacksonville Intl., returning Tue, May 12, priced at $183 found 3 days ago
Frontier Airlines
Wed, Apr 8 - Fri, Apr 24
ATL
Hartsfield-Jackson Atlanta Intl.
JAX
Jacksonville Intl.
$190 Roundtrip, found 6 days ago
$190
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Wed, Apr 8 from Hartsfield-Jackson Atlanta Intl. to Jacksonville Intl., returning Fri, Apr 24, priced at $190 found 6 days ago
Frontier Airlines
Sun, Apr 12 - Sat, Apr 18
ATL
Hartsfield-Jackson Atlanta Intl.
JAX
Jacksonville Intl.
$192 Roundtrip, found 5 hours ago
$192
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Sun, Apr 12 from Hartsfield-Jackson Atlanta Intl. to Jacksonville Intl., returning Sat, Apr 18, priced at $192 found 5 hours ago
Frontier Airlines
Thu, Apr 9 - Fri, Apr 17
ATL
Hartsfield-Jackson Atlanta Intl.
JAX
Jacksonville Intl.
$193 Roundtrip, found 4 days ago
$193
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Apr 9 from Hartsfield-Jackson Atlanta Intl. to Jacksonville Intl., returning Fri, Apr 17, priced at $193 found 4 days ago
Frontier Airlines
Tue, May 12 - Wed, May 27
DTW
Detroit Metropolitan Wayne County
JAX
Jacksonville Intl.
$206 Roundtrip, found 1 hour ago
$206
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Tue, May 12 from Detroit Metropolitan Wayne County to Jacksonville Intl., returning Wed, May 27, priced at $206 found 1 hour ago
Delta
Sun, Apr 12 - Mon, Apr 27
ATL
Hartsfield-Jackson Atlanta Intl.
TLH
Tallahassee Intl.
$225 Roundtrip, found 4 days ago
$225
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Apr 12 from Hartsfield-Jackson Atlanta Intl. to Tallahassee Intl., returning Mon, Apr 27, priced at $225 found 4 days ago
Bargain Flight
Wed, Jun 3 - Wed, Jun 10
DTW
Detroit Metropolitan Wayne County
JAX
Jacksonville Intl.
$239 Roundtrip, found 3 days ago
$239
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Jacksonville Intl., returning Wed, Jun 10, priced at $239 found 3 days ago
JetBlue Airways
Wed, Jun 3 - Wed, Jun 10
DTW
Detroit Metropolitan Wayne County
JAX
Jacksonville Intl.
$241 Roundtrip, found 3 days ago
$241
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Jacksonville Intl., returning Wed, Jun 10, priced at $241 found 3 days ago
Delta
Sat, Apr 11 - Sat, Apr 18
ATL
Hartsfield-Jackson Atlanta Intl.
VLD
Valdosta Regional
$245 Roundtrip, found 6 days ago
$245
Roundtrip
found 6 days ago
Select Delta flight, departing Sat, Apr 11 from Hartsfield-Jackson Atlanta Intl. to Valdosta Regional, returning Sat, Apr 18, priced at $245 found 6 days ago
Bargain Flight
Tue, Apr 28 - Sat, May 9
CID
Eastern Iowa
JAX
Jacksonville Intl.
$269 Roundtrip, found 3 days ago
$269
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Tue, Apr 28 from Eastern Iowa to Jacksonville Intl., returning Sat, May 9, priced at $269 found 3 days ago
American Airlines
Wed, Apr 8 - Mon, Apr 27
ATL
Hartsfield-Jackson Atlanta Intl.
TLH
Tallahassee Intl.
$278 Roundtrip, found 5 days ago
$278
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Apr 8 from Hartsfield-Jackson Atlanta Intl. to Tallahassee Intl., returning Mon, Apr 27, priced at $278 found 5 days ago
Delta
Wed, May 20 - Sat, May 30
CID
Eastern Iowa
TLH
Tallahassee Intl.
$338 Roundtrip, found 5 days ago
$338
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, May 20 from Eastern Iowa to Tallahassee Intl., returning Sat, May 30, priced at $338 found 5 days ago
Delta
Tue, Jun 9 - Sat, Jun 27
DTW
Detroit Metropolitan Wayne County
TLH
Tallahassee Intl.
$380 Roundtrip, found 5 days ago
$380
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Jun 9 from Detroit Metropolitan Wayne County to Tallahassee Intl., returning Sat, Jun 27, priced at $380 found 5 days ago
American Airlines
Wed, Mar 18 - Fri, Mar 20
ATL
Hartsfield-Jackson Atlanta Intl.
GNV
Gainesville Regional
$807 Roundtrip, found 1 day ago
$807
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 18 from Hartsfield-Jackson Atlanta Intl. to Gainesville Regional, returning Fri, Mar 20, priced at $807 found 1 day ago

Cheap Flights to O Brien

Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to O Brien

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the null airport.

What is the cheapest month to fly to O Brien?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to O Brien?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to O Brien.

What airport is best to fly into O Brien?

When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.

How much are flights to O Brien?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $176, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to O Brien?

The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $176 right now, why wait?

O Brien Flight Information
Destination airport
Jacksonville Intl.
Destination airport IATA code
JAX
Roundtrip price
$176

Last Minute Hotel Deals in O Brien

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
Book a stay at this business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
The staff was very nice and very helpful. We enjoyed our stay. We would stay with them again.

Reviewed on Mar 15, 2026

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Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,080 reviews)
Nice stay, great bed, conveniente to the highway.

Reviewed on Mar 16, 2026

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La Quinta Inn & Suite by Wyndham Lake City
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,026 reviews)
Room was very lg and spacious for a regular room. Nice amenities and great breakfast. Love that breakfast lasted until 10am instead of ending it early like most hotels and same with the 12pm checkout instead of the usual 10 or 11. Staff was very friendly! No complaints at all!

Reviewed on Mar 15, 2026

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Best Western Plus Lake City
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337 High Springs FL
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ruth B. Kirby Gilchrist Blue Springs State Park and ...
Get rates
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129 Live Oak FL
Book a stay at this business-friendly hotel in Live Oak. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (808 reviews)
Friendly staff. Nice pool. Rooms smelled musty.

Reviewed on Mar 16, 2026

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Holiday Inn Express & Suites Live Oak by IHG
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2 out of 5
3835 West US Highway 90 Lake City FL
Stay at this motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,011 reviews)
Rooms are small but serviceable.

Reviewed on Mar 16, 2026

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Americas Best Value Inn Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,007 reviews)
Great

Reviewed on Mar 16, 2026

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Tru by Hilton Lake City
Comfort Suites Lake City

Comfort Suites Lake City

2.5 out of 5
3690 W Us Highway 90 Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,005 reviews)
Needs a lot of TLC. Breakfast was pretty pitiful. Most of our party skipped breakfast and we got something down the road.

Reviewed on Mar 11, 2026

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Comfort Suites Lake City
See all 365 properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.