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Kirksville

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Kirksville Flights as Low as $318

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$318 Roundtrip, found 10 hours ago
$318
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $318 found 10 hours ago
United
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$318 Roundtrip, found 10 hours ago
$318
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $318 found 10 hours ago
United
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$324 Roundtrip, found 10 hours ago
$324
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $324 found 10 hours ago
United
Tue, May 12 - Tue, May 19
AUS
Austin-Bergstrom Intl.
COU
Columbia Regional
$336 Roundtrip, found 9 hours ago
$336
Roundtrip
found 9 hours ago
Select United flight, departing Tue, May 12 from Austin-Bergstrom Intl. to Columbia Regional, returning Tue, May 19, priced at $336 found 9 hours ago
American Airlines
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$341 Roundtrip, found 10 hours ago
$341
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $341 found 10 hours ago
United
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$356 Roundtrip, found 10 hours ago
$356
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $356 found 10 hours ago
United
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$361 Roundtrip, found 10 hours ago
$361
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $361 found 10 hours ago
American Airlines
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$368 Roundtrip, found 10 hours ago
$368
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $368 found 10 hours ago
United
Tue, May 12 - Tue, May 19
AUS
Austin-Bergstrom Intl.
COU
Columbia Regional
$372 Roundtrip, found 9 hours ago
$372
Roundtrip
found 9 hours ago
Select United flight, departing Tue, May 12 from Austin-Bergstrom Intl. to Columbia Regional, returning Tue, May 19, priced at $372 found 9 hours ago
American Airlines
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$384 Roundtrip, found 10 hours ago
$384
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $384 found 10 hours ago
United
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$389 Roundtrip, found 10 hours ago
$389
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $389 found 10 hours ago
American Airlines
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$391 Roundtrip, found 10 hours ago
$391
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $391 found 10 hours ago
United
Tue, May 12 - Tue, May 19
AUS
Austin-Bergstrom Intl.
COU
Columbia Regional
$397 Roundtrip, found 9 hours ago
$397
Roundtrip
found 9 hours ago
Select United flight, departing Tue, May 12 from Austin-Bergstrom Intl. to Columbia Regional, returning Tue, May 19, priced at $397 found 9 hours ago
American Airlines
Wed, Jun 3 - Sat, Jun 6
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$398 Roundtrip, found 10 hours ago
$398
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Wed, Jun 3 from Detroit Metropolitan Wayne County to Columbia Regional, returning Sat, Jun 6, priced at $398 found 10 hours ago
United
Sat, May 9 - Fri, May 29
SNA
John Wayne
COU
Columbia Regional
$464 Roundtrip, found 1 day ago
$464
Roundtrip
found 1 day ago
Select United flight, departing Sat, May 9 from John Wayne to Columbia Regional, returning Fri, May 29, priced at $464 found 1 day ago
United
Fri, May 1 - Mon, May 4
CHS
Charleston Intl.
COU
Columbia Regional
$473 Roundtrip, found 10 hours ago
$473
Roundtrip
found 10 hours ago
Select United flight, departing Fri, May 1 from Charleston Intl. to Columbia Regional, returning Mon, May 4, priced at $473 found 10 hours ago

Cheap Flights to Kirksville

Fall in love at first flight with your vacation to Kirksville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Kirksville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Kirksville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Kirksville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Kirksville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the COU airport.

What is the cheapest month to fly to Kirksville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Kirksville are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Kirksville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Kirksville.

What airport is best to fly into Kirksville?

When you’re planning your trip to Kirksville, convenience is the name of the game. Luckily, Kirksville Kirksville Municipal Airport is nearby so you can deplane and get going on checking off everything on your Kirksville must-do list.

How much are flights to Kirksville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Kirksville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $318, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Kirksville?

The trick to saving a stack of cash on your flight to Kirksville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $318 right now, why wait?

Kirksville Flight Information
Destination airport
Columbia Regional
Destination airport IATA code
COU
Roundtrip price
$318

Last Minute Hotel Deals in Kirksville

Super 8 by Wyndham Kirksville-University Area

Super 8 by Wyndham Kirksville-University Area

2.5 out of 5
1101 Country Club Dr Kirksville MO
Book a stay at this golf hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Thousand Hills State Park is located ...
9.2/10 Wonderful! (191 reviews)
Had a great stay at what appeared to be a recently updated hotel. Everything looked and felt new. Room was very clean and the hot breakfast was the biggest surprise. The breakfast attendant made sure everything was perfect and clean. Prices were reasonable and located next to a wonderful steak house. ...

Reviewed on Apr 21, 2026

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Super 8 by Wyndham Kirksville-University Area
Baymont by Wyndham Kirksville University Area

Baymont by Wyndham Kirksville University Area

2.5 out of 5
2702 South Franklin Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (904 reviews)
The room was really clean. The staff was very friendly. Even though the property is dated, the bed was comfortable. It was very quiet which I enjoy. I would stay there again

Reviewed on Apr 26, 2026

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Baymont by Wyndham Kirksville University Area
Hampton Inn Kirksville

Hampton Inn Kirksville

2.5 out of 5
2604 N. Baltimore Street Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (611 reviews)
Clean, easy to get too, next to a Walmart if need anything. Pool was closed but didn't impact my family. Continental breakfast was as expected but it was nice for it to go later, seems like most end at 8 or 9 and this breakfast went to 10 on a Saturday.

Reviewed on Apr 19, 2026

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Hampton Inn Kirksville
Days Inn by Wyndham Kirksville

Days Inn by Wyndham Kirksville

2 out of 5
3805 S Baltimore St Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,001 reviews)
Very disappointed in property. bed very uncomfortable, no pool or hot tub, no continental breakfast. amenities were advertised but not offered. many rooms had no hot water. the room discount of $20 off wasn't enough. lots of family stayed there, 5 rooms total for a wedding. not having a pool was ...

Reviewed on Apr 19, 2026

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Days Inn by Wyndham Kirksville
Holiday Inn Express & Suites Kirksville - University Area by IHG

Holiday Inn Express & Suites Kirksville - University Area by IHG

2.5 out of 5
2523 South Franklin St. Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (531 reviews)
The staff was very friendly and helpful. The only complaint is that the floors are very squeaky. I would request the top floor next time.

Reviewed on Apr 23, 2026

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Holiday Inn Express & Suites Kirksville - University Area by IHG
Quality Inn Kirksville

Quality Inn Kirksville

2.5 out of 5
2209 N. Baltimore Street Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
7.6/10 Good! (401 reviews)
Room smelled musty every day of the 3 night stay. Breakfast was standard fine day 1. It decreased in quality each day till day 3 when the biscuits and bagals were brick hard and the sausages were shriveled. The food was obviously reheated each day and not "fresh" as they claim. The waffle mix was ...

Reviewed on Apr 19, 2026

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Quality Inn Kirksville
Knights Inn Kirksville

Knights Inn Kirksville

1.5 out of 5
2521 South Franklin Street Kirksville MO
Stay at this motel in Kirksville. Enjoy free parking, a garden, and a picnic area. Popular attraction Thousand Hills State Park is located nearby.
7.2/10 Good! (252 reviews)
Ppl were very kind, rooms were clean, check in to make sure we didn’t need anything.

Reviewed on Apr 4, 2026

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Knights Inn Kirksville
Thousand Hills

Thousand Hills

2 out of 5
20431 Missouri 157 Kirksville MO
Stay at this hotel in Kirksville. Enjoy free parking, patios, and rainfall showerheads. Popular attraction Thousand Hills State Park is located nearby.
9.2/10 Wonderful! (15 reviews)
Great location, cabin overlooking lake. Good food at restaurant. We sat on covered patio on lake

Reviewed on Apr 3, 2026

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Thousand Hills
See all 53 properties in Kirksville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Hotels With Free Airport Shuttle

Days Inn by Wyndham Kirksville

Days Inn by Wyndham Kirksville

2 out of 5
3805 S Baltimore St Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,001 reviews)
Very disappointed in property. bed very uncomfortable, no pool or hot tub, no continental breakfast. amenities were advertised but not offered. many rooms had no hot water. the room discount of $20 off wasn't enough. lots of family stayed there, 5 rooms total for a wedding. not having a pool was ...

Reviewed on Apr 19, 2026

Get rates
Days Inn by Wyndham Kirksville
See all 53 properties in Kirksville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.