Search Cheap Flights to
Kirksville

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Kirksville Flights as Low as $418

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Fri, May 30 - Mon, Jun 2
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$418 Roundtrip, found 6 days ago
$418
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, May 30 from Detroit Metropolitan Wayne County to Columbia Regional, returning Mon, Jun 2, priced at $418 found 6 days ago
American Airlines
Fri, May 30 - Mon, Jun 2
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$427 Roundtrip, found 6 days ago
$427
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, May 30 from Detroit Metropolitan Wayne County to Columbia Regional, returning Mon, Jun 2, priced at $427 found 6 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
MSY
Louis Armstrong New Orleans Intl.
COU
Columbia Regional
$450 Roundtrip, found 9 hours ago
$450
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Louis Armstrong New Orleans Intl. to Columbia Regional, returning Sat, Oct 11, priced at $450 found 9 hours ago
American Airlines
Fri, May 30 - Mon, Jun 2
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$469 Roundtrip, found 6 days ago
$469
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, May 30 from Detroit Metropolitan Wayne County to Columbia Regional, returning Mon, Jun 2, priced at $469 found 6 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
MOB
Mobile Regional
COU
Columbia Regional
$476 Roundtrip, found 9 hours ago
$476
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Mobile Regional to Columbia Regional, returning Sat, Oct 11, priced at $476 found 9 hours ago
American Airlines
Fri, May 30 - Mon, Jun 2
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$478 Roundtrip, found 6 days ago
$478
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, May 30 from Detroit Metropolitan Wayne County to Columbia Regional, returning Mon, Jun 2, priced at $478 found 6 days ago
American Airlines
Wed, Oct 8 - Tue, Oct 14
PNS
Pensacola Intl.
COU
Columbia Regional
$480 Roundtrip, found 9 hours ago
$480
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 8 from Pensacola Intl. to Columbia Regional, returning Tue, Oct 14, priced at $480 found 9 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 18
GPT
Gulfport - Biloxi Intl.
COU
Columbia Regional
$480 Roundtrip, found 9 hours ago
$480
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Gulfport - Biloxi Intl. to Columbia Regional, returning Sat, Oct 18, priced at $480 found 9 hours ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
MOB
Mobile Regional
COU
Columbia Regional
$486 Roundtrip, found 9 hours ago
$486
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Oct 11 from Mobile Regional to Columbia Regional, returning Tue, Oct 14, priced at $486 found 9 hours ago
American Airlines
Fri, Oct 10 - Sun, Oct 12
MSY
Louis Armstrong New Orleans Intl.
COU
Columbia Regional
$490 Roundtrip, found 9 hours ago
$490
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Fri, Oct 10 from Louis Armstrong New Orleans Intl. to Columbia Regional, returning Sun, Oct 12, priced at $490 found 9 hours ago
American Airlines
Fri, May 30 - Mon, Jun 2
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$495 Roundtrip, found 6 days ago
$495
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, May 30 from Detroit Metropolitan Wayne County to Columbia Regional, returning Mon, Jun 2, priced at $495 found 6 days ago
American Airlines
Fri, May 30 - Mon, Jun 2
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$504 Roundtrip, found 6 days ago
$504
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, May 30 from Detroit Metropolitan Wayne County to Columbia Regional, returning Mon, Jun 2, priced at $504 found 6 days ago
American Airlines
Wed, Oct 8 - Mon, Oct 20
PNS
Pensacola Intl.
COU
Columbia Regional
$507 Roundtrip, found 9 hours ago
$507
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 8 from Pensacola Intl. to Columbia Regional, returning Mon, Oct 20, priced at $507 found 9 hours ago
American Airlines
Tue, May 13 - Wed, May 21
FNT
Bishop Intl.
COU
Columbia Regional
$510 Roundtrip, found 9 hours ago
$510
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, May 13 from Bishop Intl. to Columbia Regional, returning Wed, May 21, priced at $510 found 9 hours ago
American Airlines
Sat, May 10 - Tue, May 20
DTW
Detroit Metropolitan Wayne County
COU
Columbia Regional
$510 Roundtrip, found 9 hours ago
$510
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, May 10 from Detroit Metropolitan Wayne County to Columbia Regional, returning Tue, May 20, priced at $510 found 9 hours ago
American Airlines
Sat, Oct 11 - Mon, Oct 20
PNS
Pensacola Intl.
COU
Columbia Regional
$513 Roundtrip, found 9 hours ago
$513
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Oct 11 from Pensacola Intl. to Columbia Regional, returning Mon, Oct 20, priced at $513 found 9 hours ago

Cheap Flights to Kirksville

Fall in love at first flight with your vacation to Kirksville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Kirksville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Kirksville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Kirksville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Kirksville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the COU airport.

What is the cheapest month to fly to Kirksville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Kirksville are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Kirksville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Kirksville.

What airport is best to fly into Kirksville?

When you’re planning your trip to Kirksville, convenience is the name of the game. Luckily, Kirksville Kirksville Municipal Airport is nearby so you can deplane and get going on checking off everything on your Kirksville must-do list.

How much are flights to Kirksville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Kirksville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $418, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Kirksville?

The trick to saving a stack of cash on your flight to Kirksville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $418 right now, why wait?

Kirksville Flight Information
Destination airport
Columbia Regional
Destination airport IATA code
COU
Roundtrip price
$417

Last Minute Hotel Deals in Kirksville

Hampton Inn Kirksville
Hampton Inn Kirksville
2.5 out of 5
2604 N. Baltimore Street, Kirksville, MO
The price is $143 per night from May 11 to May 12
$143
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (480 reviews)
"Clean and quiet."

Reviewed on Apr 25, 2025

Hampton Inn Kirksville
Days Inn by Wyndham Kirksville
Days Inn by Wyndham Kirksville
2 out of 5
3805 S Baltimore St, Kirksville, MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (976 reviews)
"The check-in was great and we had a minor issue about checking in and they solved it instantly. Breakfast was an absolute minimum. In fact, it was pitiful. Room was clean and warm even though the cover over the heater was messed up."

Reviewed on Apr 6, 2025

Get rates
Days Inn by Wyndham Kirksville
Baymont by Wyndham Kirksville University Area
Baymont by Wyndham Kirksville University Area
2.5 out of 5
2702 South Franklin, Kirksville, MO
The price is $88 per night from May 25 to May 26
$88
includes taxes & fees
May 25 - May 26
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (855 reviews)
A reasonably good place to stay
"I switched hotels from super cheap to a bit more expensive. The bed was soft and comfortable. Other than a staff member walking into my room unannounced (no explanation) my stay was fine. Acceptable breakfast."

Reviewed on Mar 24, 2025

Baymont by Wyndham Kirksville University Area
Super 8 by Wyndham Kirksville-University Area
Super 8 by Wyndham Kirksville-University Area
2.5 out of 5
1101 Country Club Dr, Kirksville, MO
The price is $72 per night from May 4 to May 5
$72
includes taxes & fees
May 4 - May 5
Book a stay at this golf hotel in Kirksville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Jacob's Vineyard & Winery and Thousand ...
"We come to the Kirksville area annually but in years past, we've avoided staying with this particular property due to increased neglect of facilities . Having recently learned of management and property updates, we decided to give Super 8 in Kirksville Missouri another try. Are we ever glad we did! ..."

Reviewed on Apr 27, 2025

Super 8 by Wyndham Kirksville-University Area
Holiday Inn Express & Suites Kirksville - University Area by IHG
Holiday Inn Express & Suites Kirksville - University Area by IHG
2.5 out of 5
2523 South Franklin St., Kirksville, MO
The price is $162 per night from May 4 to May 5
$162
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (472 reviews)
"Staff is incredibly nice"

Reviewed on Apr 5, 2025

Holiday Inn Express & Suites Kirksville - University Area by IHG
Knights Inn Kirksville
Knights Inn Kirksville
1.5 out of 5
2521 South Franklin Street, Kirksville, MO
The price is $72 per night from May 1 to May 2
$72
includes taxes & fees
May 1 - May 2
Stay at this motel in Kirksville. Enjoy free parking, cable TV channels, and an in-room coffeemaker. Popular attractions Jacob's Vineyard & Winery and Thousand ...
7.2/10 Good! (234 reviews)
Clean, friendly & roomy
"The staff is friendly. The hotel is clean and has large rooms. It is outdated but it's clear they are working on updating the rooms. There is no continental breakfast (which we knew from staying here on another trip) and the staff lets you know of the on-line error."

Reviewed on Apr 15, 2025

Knights Inn Kirksville
Quality Inn Kirksville
Quality Inn Kirksville
2.5 out of 5
2209 N Baltimore St, Kirksville, MO
The price is $89 per night from May 25 to May 26
$89
includes taxes & fees
May 25 - May 26
Book a stay at this business-friendly hotel in Kirksville. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
7.4/10 Good! (367 reviews)
"No problem with cleanliness. Lighting was not good. Location good, close to food places and Walmart."

Reviewed on Apr 21, 2025

Quality Inn Kirksville
Budget Host Village Inn
Budget Host Village Inn
2 out of 5
1304 S Baltimore, Kirksville, MO
The price is $63 per night from May 11 to May 12
$63
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly motel in Kirksville. Enjoy free WiFi, free parking, and room service. Popular attractions Jacob's Vineyard & Winery and ...
6/10 (120 reviews)
"It was in a busy spot but so chill"

Reviewed on May 5, 2024

Budget Host Village Inn
See all 33 properties in Kirksville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Hotels With Free Airport Shuttle

Days Inn by Wyndham Kirksville
Days Inn by Wyndham Kirksville
2 out of 5
3805 S Baltimore St, Kirksville, MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (976 reviews)
"The check-in was great and we had a minor issue about checking in and they solved it instantly. Breakfast was an absolute minimum. In fact, it was pitiful. Room was clean and warm even though the cover over the heater was messed up."

Reviewed on Apr 6, 2025

Get rates
Days Inn by Wyndham Kirksville
See all 33 properties in Kirksville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.