Yes. Please keep in mind that when booking on Hotwire, the exact flight times are shown after you book. Therefore, arrivals into your port city should be booked for the day before the cruise ship leaves, and departures booked for the day after the cruise ship returns.
For example, if your cruise dates are Monday-Friday, book a departure flight on Sunday and a return flight on Saturday. If you were to book flights on Monday and Friday, the flight times may not correspond to the cruise ship's arrival and departure schedule. Remember all Hotwire airline ticket bookings are nonrefundable.