Yes. At check-in, the driver will need to present a valid driver's license and credit card -- both must match the driver's name. (Even if you paid for the car rental reservation on the Hotwire site, the driver will need to present his/her own credit card at pick-up.)
If the driver's license is in a language other than English, an International Driver's Permit is recommended. In all cases, a valid driver's license issued in your home country must be provided (whether or not you possess an International Driver's Permit). You will not be allowed to rent a car with only an International Driver's Permit.
For rental deposits in the U.S. and Canada, you should have at least $200 in available funds. If you are using a debit card, the car rental company will place a hold on your deposit amount, and you will not have access to these funds until the car is returned. For rentals outside of the U.S. and Canada, you may need as much as $1000 in available funds, and you will be required to use a credit card for deposit. Debit cards will not be accepted for deposit on international rentals.
If optional items are elected for purchase (e.g., insurance), additional available credit will be required. Please note that the amount of available credit that is necessary varies, depending on the type of car and the rental period.
Note that many car rental companies will not accept a debit card as a deposit when the vehicle is picked up, and you will be denied rental. You can choose to see only results for companies that accept debit cards for deposit at pick-up. Since this will limit your search range, the best deal available might not show up in your search results.
Be aware that car rental companies will not accept a prepaid or 'stored value' card, including those showing a MasterCard or Visa logo.