Search Cheap Flights to
Madre de Dios Region from

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Flights to Madre de Dios Region starting at

Have you been telling yourself, “2025 is the year I travel more and sit less”? Well, here we are and there you are. So, where are you going? Looks like a flight to Madre de Dios Region is calling. Good thing we can help you bag that flight out of town for cheap, so you can get your resolutions resolved.

Travel like you mean it

When you land it’s not straight to the tourist traps for you. You have things to do and see in Madre de Dios Region that aren’t on a map or in the “Best of. . .” guides. You know this region is filled with hidden haunts, locals-only know favorites, and the off-beat-so-weird-it’s-amazing places. And you plan to find every last one of them. Good thing you’ll save a grip of cash on your flight so you can daytrip far and wide.

You won’t have to wing it

So how do you score that killer deal on a flight to Madre de Dios Region? Easy, go through us. These aren’t pie in the sky deals, but ones you can actually score. Filter flights to Madre de Dios Region by:

  • Hotwire Hot Rate: Do you have a flexible schedule? Hit up the Hotwire Hot Rate and land a super cheap flight to Madre de Dios Region. We’ll reveal the airline and exact time after you book.
  • Price: How low can we go? Find out. We have prices from to .
  • Duration: Want to get to Madre de Dios Region as fast as you can? Or maybe you don’t mind taking your time to save a few bucks here and there.
  • Departure or Arrival: Like to arrive in the a.m. to get your day going? Or are you a night owl that knows the best fun happens late night? The choice is yours.

So are you going to live up to those travel plans or kick the can to next year? Book your flight to Madre de Dios Region today and get going.

Last Minute Hotel Deals in Madre de Dios Region

IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

3 out of 5
Tambopata KM. 7 Otr. Carretera Bajo, Tambopata, Madre de Dios
Stay at this 3-star all-inclusive hotel in Tambopata. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Puerto Capitanía and Puerto Maldonado ...
9/10 Wonderful! (4 reviews)
"24/7 electricity as well as WiFi which many other properties didn’t have. Close to the city but still in the jungle. Pool. Good excursions and tour guides. Dog on site who lives at the property. Good meals."

Reviewed on Sep 9, 2025

Opens in a new windowIKAM Riverview Amazon Lodge - Asociado Casa Andina
Libelula Hotel

Libelula Hotel

2 out of 5
Jr Puno No. 429, Tambopata, Madre de Dios
Stay at this hostal in Tambopata. Enjoy free WiFi, daily housekeeping, and cable TV channels. Popular attractions Puerto Maldonado Plaza de Armas and Maldonado ...
8.8/10 Excellent! (17 reviews)
"Great stay, friendly owners and staff."

Reviewed on Jun 22, 2025

Opens in a new windowLibelula Hotel
Inkaterra Reserva Amazonica

Inkaterra Reserva Amazonica

4 out of 5
Madre De Dios River Km. 15, Las Piedras, Madre de Dios
Stay at this 4-star spa hotel in Las Piedras. Enjoy free breakfast, a full-service spa, and a free airport shuttle. Popular attractions Island of Monkeys and ...
9.2/10 Wonderful! (42 reviews)
"Lovely property, gorgeous living spaces, excellent excusions included. Only issue was the generator for the limited electricity kept going out while we were there"

Reviewed on Sep 16, 2024

Opens in a new windowInkaterra Reserva Amazonica
Save an average of 15% on thousands of hotels when you're signed in
Hacienda Herrera Tambopata

Hacienda Herrera Tambopata

2.5 out of 5
km4 rio bajo madre de dios, Tambopata, tambopata
Book a stay at this beach farm stay in Tambopata. Enjoy free breakfast, a free airport shuttle, and a 24-hour front desk. Popular attractions Puerto Maldonado ...
8.6/10 Excellent! (3 reviews)
"Kenny is the owner and he was super helpful with coordinating our day trips and getting us boat rides to the city. The room with the private bathroom was worth it. Not many bugs got inside the room so that was great! Food was average but all included. No a/c but fans by the bed! Overall great ..."

Reviewed on May 27, 2025

Opens in a new windowHacienda Herrera Tambopata
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.