Hotels Near
Serra Mesa

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Featured Serra Mesa Hotels

California Suites Hotel
California Suites Hotel
2 out of 5
5415 Clairemont Mesa Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
6.8/10 (1,071 reviews)
"My wife n i enjoy setting at the water fountain n looking a the beautiful green landscape."

Reviewed on Nov 23, 2023

California Suites Hotel
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the restaurant and the helpful staff ...
8/10 Very Good! (5,735 reviews)
"Harbor View Was great. It did get a little noisy at night, so we couldn't keep our sliding door open, but Had a great time anyways. Thank you."

Reviewed on Nov 27, 2023

Wyndham San Diego Bayside
Hilton San Diego Bayfront
Hilton San Diego Bayfront
4 out of 5
1 Park Blvd, San Diego, CA
Stay at this 4-star spa hotel in San Diego. Enjoy 2 bars/lounges, a full-service spa, and breakfast. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,399 reviews)
"Loved the view"

Reviewed on Nov 28, 2023

Hilton San Diego Bayfront
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (3,386 reviews)
Lovely place!!!
"Wonderful stay at an amazing place with the best view! The staff was so kind and got me a room with a view and included a whole list of amenities included with my stay. A very family friendly place but also a nice place for a solo trip."

Reviewed on Nov 28, 2023

Manchester Grand Hyatt San Diego
Sheraton Mission Valley San Diego Hotel
Sheraton Mission Valley San Diego Hotel
4 out of 5
1433 Camino Del Rio S, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast, and 24-hour room service. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,018 reviews)
"I liked that it is near shopping and dining area breakfast was very expensive for the quality"

Reviewed on Nov 26, 2023

Sheraton Mission Valley San Diego Hotel
Embassy Suites by Hilton San Diego La Jolla
Embassy Suites by Hilton San Diego La Jolla
3.5 out of 5
4550 La Jolla Village Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, 2 restaurants, and WiFi. Our guests praise the breakfast and the pool in our ...
8.8/10 Excellent! (1,010 reviews)
"가족과 이용했는데 편안하고 쾌적했습니다."

Reviewed on Nov 26, 2023

Embassy Suites by Hilton San Diego La Jolla
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
Stay at this 4-star spa hotel in San Diego. Enjoy 2 outdoor pools, 4 restaurants, and a marina. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (1,932 reviews)
"Awesome"

Reviewed on Nov 25, 2023

Marriott Marquis San Diego Marina
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Stay at this 4-star beach hotel in San Diego. Enjoy 2 restaurants, a beach locale, and a full-service spa. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,043 reviews)
"Gorgeous grounds and our room was good size and very clean"

Reviewed on Nov 25, 2023

San Diego Mission Bay Resort
Hampton Inn San Diego-Downtown
Hampton Inn San Diego-Downtown
2.5 out of 5
San Diego
Stay at this business-friendly vacation home in San Diego. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,144 reviews)
"The location is great as you can walk to restaurants in Little Italy as well as to the waterfront parks and museums. The staff at the front desk were fabulous! Breakfast was as expected. The elevators could use a tune up."

Reviewed on Nov 27, 2023

Hampton Inn San Diego-Downtown
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the restaurant and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,887 reviews)
"Walking distance to Gaslamp"

Reviewed on Nov 28, 2023

Hard Rock Hotel San Diego
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and the ...
7/10 Good! (1,987 reviews)
"saw some damaged area or water damaged area on the door, lots of constructions so it could get a bit loud."

Reviewed on Nov 27, 2023

Wyndham Garden San Diego Near SeaWorld
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Stay at this 4-star beach resort in San Diego. Enjoy 5 outdoor pools, 3 restaurants, and a marina. Our guests praise the pool and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,879 reviews)
"We loveb this hotel. But this time there were 3 trash bags in front of our door on our porch that were left there the whole time (from the previous people in the room)"

Reviewed on Nov 27, 2023

Paradise Point Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Serra Mesa

San Diego is a city that has a lot going on, but you have your sights set on Serra Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Serra Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Serra Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Serra Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Serra Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Serra Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Serra Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $78
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Serra Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.