Hotels Near
Otay Mesa

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Featured Otay Mesa Hotels

Best Western Seven Seas
Best Western Seven Seas
3 out of 5
411 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 spa tubs. Our guests praise the pool and the helpful staff in ...
7.2/10 Good! (2,364 reviews)
"Overall is good . But no free breakfast and paid breakfast is not that impressive, breakfast price is also high."

Reviewed on Mar 18, 2024

Best Western Seven Seas
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundable
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (3,395 reviews)
"Very clean and well managed! Ice machine was broken but room service sent an ice bucket up right away."

Reviewed on Mar 18, 2024

Manchester Grand Hyatt San Diego
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and the ...
7/10 Good! (2,389 reviews)
Spring Break weekend getaway..
"Spring break weekend get away in Mission beach. Easy access off Sports Arena Blvd. close to great dining & minutes from Belmont Park & downtown San Diego."

Reviewed on Mar 17, 2024

Wyndham Garden San Diego Near SeaWorld
Legacy Resort Hotel & Spa
Legacy Resort Hotel & Spa
4 out of 5
875 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (2,633 reviews)
"We chose the room with balcony because we wanted to soak in the sun while feeling safe in the room. Unfortunately there was spiders and spider webs all over the balcony and chairs."

Reviewed on Mar 16, 2024

Legacy Resort Hotel & Spa
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the restaurant and the helpful staff ...
8/10 Very Good! (6,058 reviews)
"Helpful staff."

Reviewed on Mar 18, 2024

Wyndham San Diego Bayside
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star family-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 poolside bars. Our guests praise the breakfast and the pool ...
8.6/10 Excellent! (2,288 reviews)
"Lovely!"

Reviewed on Mar 15, 2024

The Dana on Mission Bay
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,918 reviews)
"Amazing property and felt very safe. Staff was so helpful and friendly. Love this place it’s so tropical and island feels . Little pricy for parking and amenities but loved this place ."

Reviewed on Mar 15, 2024

Paradise Point Resort & Spa
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...
8.6/10 Excellent! (2,599 reviews)
"This is an older hotel. My room was clean and the bed was good, too. I didn’t use the pool, but it looked nice. They charge $15 a day parking which is BS. Two restaurants. One breakfast one dinner. I ate at both and they were quite adequate. The property was dated but well kept. Kitschy."

Reviewed on Mar 17, 2024

Kings Inn San Diego
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 2 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,490 reviews)
Great stay and very comfortable
"We stay here on our wedding night and my parents called ahead and spoke with the hotel concierge and asked if they could do anything special. They had a bottle of champange and chocolate covered strawberries already waiting in our room for us. The view was spectacular too. It made for a fantastic ..."

Reviewed on Mar 17, 2024

Hyatt Regency Mission Bay Spa and Marina
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a beach locale. Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (1,035 reviews)
"Proximity"

Reviewed on Mar 16, 2024

San Diego Mission Bay Resort
The Sofia Hotel
The Sofia Hotel
3.5 out of 5
150 W Broadway, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and room service. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (1,293 reviews)
"location is great。"

Reviewed on Mar 16, 2024

The Sofia Hotel
Bahia Resort Hotel
Bahia Resort Hotel
3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star beach resort in San Diego. Enjoy free parking, a marina, and a beach locale. Our guests praise the pool and the restaurant in our reviews. ...
8.4/10 Very Good! (1,240 reviews)
"I can’t say enough good things about this place. This was the absolute best place for our vacation with kids. Resort was perfect and an easy walk to Mission Beach. Every staff member we talked to was exceptional. We will be back annually."

Reviewed on Mar 16, 2024

Bahia Resort Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $94
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.