Hotels Near
Medical District

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Featured Medical District Hotels

Courtyard Marriott Greenville

Courtyard Marriott Greenville

3 out of 5
2225 Stantonsburg Rd Greenville NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.6/10 Excellent! (880 reviews)
The room was clean and very comfortable. We have stayed in the hotel before and are very happy with the staff and ammendities.

Reviewed on Nov 17, 2025

Courtyard Marriott Greenville
Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG

3 out of 5
930 Crosswind Street Greenville NC
Fully refundable
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Guy Smith Stadium and North Pines are located ...
9.2/10 Wonderful! (234 reviews)
Good size ,Nice & clean room. New property!

Reviewed on Dec 12, 2025

Staybridge Suites Greenville Medical Center by IHG
Microtel Inn & Suites by Wyndham Greenville/University Medic

Microtel Inn & Suites by Wyndham Greenville/University Medic

2 out of 5
450 Moye Blvd Greenville NC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7/10 Good! (1,000 reviews)
Yes

Reviewed on Dec 9, 2025

Microtel Inn & Suites by Wyndham Greenville/University Medic
Best Western Plus Suites-Greenville

Best Western Plus Suites-Greenville

2.5 out of 5
2310 Greenville Boulevard NE Greenville NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
Room was clean, comfortable and well decorated. Bed very comfortable. Food was delicious. Hot. Great selection.

Reviewed on Dec 9, 2025

Best Western Plus Suites-Greenville
Baymont by Wyndham Greenville

Baymont by Wyndham Greenville

2.5 out of 5
3439 S Memorial Drive Greenville NC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
6.4/10 (1,006 reviews)
Breakfast was sufficient. WiFi was better this time. The beds and bedding are comfortable. Shower water pressure was great too lol

Reviewed on Dec 12, 2025

Baymont by Wyndham Greenville
Homewood Suites By Hilton Greenville, NC

Homewood Suites By Hilton Greenville, NC

3 out of 5
420 Moye Blvd Greenville NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
9.2/10 Wonderful! (306 reviews)
Room was great. Staff was indifferent.

Reviewed on Dec 15, 2025

Homewood Suites By Hilton Greenville, NC
 Comfort Inn & Suites Greenville near East Carolina University

Comfort Inn & Suites Greenville near East Carolina University

2.5 out of 5
3212 S Memorial Dr Greenville NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (390 reviews)
The lobby and the breakfast area were very clean. The room was very clean. I was happy with the experience. I would stay there again.

Reviewed on Dec 10, 2025

Comfort Inn & Suites Greenville near East Carolina University
Holiday Inn Greenville by IHG

Holiday Inn Greenville by IHG

3 out of 5
203 Greenville Blvd SW Greenville NC
Fully refundable
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,000 reviews)
Nothing stood out.

Reviewed on Nov 29, 2025

Holiday Inn Greenville by IHG
Quality Inn Greenville near University

Quality Inn Greenville near University

2.5 out of 5
821 Memorial Dr Greenville NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
Yes

Reviewed on Dec 10, 2025

Quality Inn Greenville near University
Hampton Inn Greenville

Hampton Inn Greenville

2.5 out of 5
305 Greenville Blvd Sw Greenville NC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions University Commons and Bowlero East Carolina are located ...
8.8/10 Excellent! (571 reviews)
The room was in excellent condition and very clean. There was a bit of mold along the bottom seal of the shower but nothing significant. Overall, a very good stay.

Reviewed on Dec 12, 2025

Hampton Inn Greenville
Fairfield Inn & Suites by Marriott Greenville

Fairfield Inn & Suites by Marriott Greenville

2.5 out of 5
908 Moye Blvd Greenville NC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (456 reviews)
Yes

Reviewed on Dec 3, 2025

Fairfield Inn & Suites by Marriott Greenville
Holiday Inn Express Greenville by IHG

Holiday Inn Express Greenville by IHG

2.5 out of 5
909 Moye Blvd Greenville NC
Fully refundable
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (965 reviews)
Yes

Reviewed on Nov 28, 2025

Holiday Inn Express Greenville by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical District

Greenville is a city that has a lot going on, but you have your sights set on Medical District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Greenville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $60
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical District hotel you want, book it, and never look back. Because your great escape is ahead of you.