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Hotels in Main Street Hyannis

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Choose from 5655 Main Street Hyannis Hotel Deals

Cape Sands Inn
Cape Sands Inn
2.5 out of 5
149 Main St - RT 28, West Yarmouth, MA
  • 23 min walk from John F. Kennedy Hyannis Museum
The price is $78 per night from May 15 to May 16
$78
per night
May 15 - May 16
Stay at this family-friendly motel in West Yarmouth. Enjoy free parking, a sauna, and a business center. Our guests praise the pool and the helpful staff in ...
8.4/10 Very Good! (922 reviews)
"very well nice and clean and quite, definitely staying here again."

Reviewed on Apr 20, 2024

Cape Sands Inn
Cape Cod Inn
Cape Cod Inn
2 out of 5
447 Main St, Hyannis, MA
  • 3 min walk from John F. Kennedy Hyannis Museum
The price is $95 per night from May 5 to May 6
$95
per night
May 5 - May 6
Stay at this motel in Hyannis. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.6/10 Excellent! (323 reviews)
"The staff are pretty nice. They allow me to change room to a cheaper price on very short notice. I highly recommended this hotel."

Reviewed on Oct 30, 2023

Cape Cod Inn
Americas Best Value Inn & Suites Hyannis Cape Cod
Americas Best Value Inn & Suites Hyannis Cape Cod
2 out of 5
206 Main St, Hyannis, MA
  • 6 min walk from John F. Kennedy Hyannis Museum
The price is $85 per night from May 3 to May 4
$85
per night
May 3 - May 4
Stay at this hotel in Hyannis. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the helpful staff in our reviews. Popular attractions ...
7.2/10 Good! (998 reviews)
Great stay!!!!
"My kids and I had a great time!!! Very clean and great customer service.we will be stayin again!!!"

Reviewed on Nov 10, 2023

Americas Best Value Inn & Suites Hyannis Cape Cod
Hyannis Inn
Hyannis Inn
2 out of 5
473 MAIN ST, Hyannis, MA
  • 4 min walk from John F. Kennedy Hyannis Museum
The price is $94 per night from May 1 to May 2
$94
per night
May 1 - May 2
Stay at this motel in Hyannis. Enjoy free WiFi, free parking, and a free beach shuttle. Our guests praise the pool and the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (805 reviews)
"The customer service was great. The room was clean and had everything we needed. My only complaint was the pool was only open until 5…check in at 3 and we were only there for 1 night so didn’t get to enjoy it."

Reviewed on Apr 15, 2024

Hyannis Inn
Bayside Resort Hotel
Bayside Resort Hotel
3 out of 5
225 Route 28, West Yarmouth, MA
  • 26 min walk from John F. Kennedy Hyannis Museum
The price is $125 per night from Apr 28 to Apr 29
$125
per night
Apr 28 - Apr 29
Stay at this 3-star beach hotel in West Yarmouth. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,006 reviews)
Bayside hotel stay
"Friendly environments, but a little noisy. Checking in was easy . Breakfast was okay, need more variety"

Reviewed on Apr 21, 2024

Bayside Resort Hotel
Sea Crest Beach Hotel
Sea Crest Beach Hotel
3.5 out of 5
350 Quaker Rd, North Falmouth, MA
  • 42 min drive from John F. Kennedy Hyannis Museum
The price is $139 per night from Apr 28 to Apr 29
$139
per night
Apr 28 - Apr 29
Stay at this beach hotel in North Falmouth. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the restaurant in our reviews. ...
7.8/10 Good! (1,001 reviews)
"The lobby was beautiful, and the staff are very nice and accommodating. It’s under construction, but even with that we had a great time and have no complaints. I do hope they upgrade the bathroom/shower soon but everything else was beautiful!!"

Reviewed on Apr 15, 2024

Sea Crest Beach Hotel
Cape Codder Resort and Spa
Cape Codder Resort and Spa
3 out of 5
1225 Iyannough Rd, Hyannis, MA
  • 5 min drive from John F. Kennedy Hyannis Museum
The price is $119 per night from Apr 28 to Apr 29
$119
per night
Apr 28 - Apr 29
Stay at this spa resort in Hyannis. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.6/10 Good! (1,014 reviews)
"Great for kids"

Reviewed on Apr 21, 2024

Cape Codder Resort and Spa
Hyannis Travel Inn
Hyannis Travel Inn
2.5 out of 5
18 North St, Hyannis, MA
  • 4 min walk from John F. Kennedy Hyannis Museum
The price is $89 per night from Apr 28 to Apr 29
$89
per night
Apr 28 - Apr 29
Stay at this hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...
9.4/10 Exceptional! (1,009 reviews)
"Great front desk service—so friendly and helpful with our questions. Great value for money. However, the bed is too soft and saggy, bathroom needs a renovation. But I would stay here for the price for what you get, but if you want a firm bed, do not stay here :)."

Reviewed on Apr 22, 2024

Hyannis Travel Inn
Chatham Bars Inn
Chatham Bars Inn
5 out of 5
297 Shore Rd, Chatham, MA
  • 38 min drive from John F. Kennedy Hyannis Museum
The price is $378 per night from Apr 28 to Apr 29
$378
per night
Apr 28 - Apr 29
Stay at this luxury resort in Chatham. Enjoy an outdoor pool, a private beach, and a full-service spa. Our guests praise the property condition in our reviews. ...
9/10 Wonderful! (684 reviews)
"Long term homeowner in proximity to CBI and first time guest. Beautiful location and grounds, but stay fell short given established reputation and the cost of accommodations, Room smelled quit musty. Decor suggested a collection of castoff furnishings from perhaps past renovations. Bathroom needed ..."

Reviewed on Apr 1, 2024

Chatham Bars Inn
Best Western Cape Cod Hotel
Best Western Cape Cod Hotel
2.5 out of 5
1470 Iyannough Rd. Rt 132, Hyannis, MA
  • 6 min drive from John F. Kennedy Hyannis Museum
The price is $98 per night from Apr 29 to Apr 30
$98
per night
Apr 29 - Apr 30
Stay at this business-friendly hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
7.2/10 Good! (1,001 reviews)
"Pool area was cold other than that it was an amazing stay"

Reviewed on Apr 24, 2024

Best Western Cape Cod Hotel
Aiden by Best Western Cape Point
Aiden by Best Western Cape Point
3 out of 5
476 Route 28, West Yarmouth, MA
  • 5 min drive from John F. Kennedy Hyannis Museum
The price is $107 per night from Apr 29 to Apr 30
$107
per night
Apr 29 - Apr 30
Stay at this 3-star business-friendly hotel in West Yarmouth. Enjoy free parking, an outdoor pool, and breakfast. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (843 reviews)
"I preferred the prior restaurant, more variety for the average person. Sorry, but not everybody likes Indian food. Maybe an acquired taste. Just being me."

Reviewed on Apr 7, 2024

Aiden by Best Western Cape Point
Anchor In Distinctive Waterfront Lodging
Anchor In Distinctive Waterfront Lodging
3 out of 5
1 South Street, Hyannis, MA
  • 8 min walk from John F. Kennedy Hyannis Museum
The price is $125 per night from Apr 30 to May 1
$125
per night
Apr 30 - May 1
Stay at this 3-star business-friendly hotel in Hyannis. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
"Clean and friendly and easy check-in."

Reviewed on Apr 17, 2024

Anchor In Distinctive Waterfront Lodging
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Main Street Hyannis

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Main Street Hyannis.

Choosing the right hotel in Massachusetts has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Main Street Hyannis’s 5,655 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $78. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Main Street Hyannis hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Main Street Hyannis. No matter your reason for visiting Main Street Hyannis, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Main Street Hyannis hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Main Street Hyannis for as low as $78.

How many hotels are there in Main Street Hyannis?

With over 5,655 hotels in Main Street Hyannis, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $78.

How to find cheap car rentals in Main Street Hyannis?

Finding a cheap car rental deal in Main Street Hyannis is as easy as scoring cheap hotels in Main Street Hyannis. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Main Street Hyannis now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Main Street Hyannis right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.